Despite the high prevalence, the neuropsychiatric disorders remain enigmatic, because there is no single factor that accounts for the large number of patients. Therefore, it has been widely speculated that epigenetic changes may play a role in the etiology of psychotic illnesses, such as schizophrenia and bipolar disorder. Most of our knowledge about the epigenetic machinery is based on viral and cancer studies. However, the number of available data in the central nervous system is also increasing. The already discovered epigenetic changes involve DNA methylation, histone modification (acetylation, methylation, phosphorylation, and others) as well as microRNA or long noncoding RNA changes both in animal models and in postmortem psychotic brains. There are a wide range of targeted molecules as well, ranging from the components of the well-known neurotransmitter systems (COMT, GAD1) to the neurotrophin factors (BDNF, reelin) or glia regulatory elements. The determination of epigenetic changes in the peripheral blood seems to be a unique possibility both for diagnosis and personalized therapy. The future could be the development of new drugs targeting the epigenetic machinery in a more specific way.
|Title of host publication||Patho-Epigenetics of Disease|
|Publisher||Springer New York|
|Number of pages||67|
|ISBN (Print)||1461433444, 9781461433446|
|Publication status||Published - Sep 1 2012|
ASJC Scopus subject areas
- Immunology and Microbiology(all)