Abstract
Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea. Antidromic electrical or chemical stimulation of trigeminal sensory nerves results in neurogenic plasma extravasation in inner ear tissues. The primary aim of this study was to reveal the possible morphological basis of cochlear vascular changes mediated by capsaicin-sensitive sensory nerves. Therefore, the distribution of SP and capsaicin receptor (transient receptor potential vanilloid type 1 - TRPV1) was investigated by double immunolabeling to demonstrate the anatomical relationships between the cochlear and vertebro-basilar blood vessels and the trigeminal sensory fiber system. Extensive TRPV1 and SP expression and co-localization were observed in axons within the adventitial layer of the basilar artery, the anterior inferior cerebellar artery, the SMA, and the radiating arterioles of the cochlea. There appears to be a functional relationship between the trigeminal ganglion and the cochlear blood vessels since electrical stimulation of the trigeminal ganglion induced significant plasma extravasation from the SMA and the radiating arterioles. The findings suggest that stimulation of paravascular afferent nerves may result in permeability changes in the basilar and cochlear vascular bed and may contribute to the mechanisms of vertebro-basilar type of headache through the release of SP and stimulation of TPVR1, respectively. We propose that vertigo, tinnitus, and hearing deficits associated with migraine may arise from perturbations of capsaicin-sensitive trigeminal sensory ganglion neurons projecting to the cochlea.
| Original language | English |
|---|---|
| Pages (from-to) | 919-927 |
| Number of pages | 9 |
| Journal | Neuroscience |
| Volume | 124 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2004 |
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Keywords
- AICA
- Anterior inferior cerebellar artery
- BA
- Basilar artery
- Blood pressure
- Bovine serum albumin
- BP
- BSA
- C-fibers
- Calcitonin gene-related peptide
- Capsaicin
- CBF
- CGRP
- CNS
- Cochlear blood flow
- Guinea-pig
- Headache
- Plasma extravasation
- Trigeminus
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries. / Vass, Z.; Dai, C. F.; Steyger, P. S.; Jancsó, G.; Trune, D. R.; Nuttall, A. L.
In: Neuroscience, Vol. 124, No. 4, 2004, p. 919-927.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries
AU - Vass, Z.
AU - Dai, C. F.
AU - Steyger, P. S.
AU - Jancsó, G.
AU - Trune, D. R.
AU - Nuttall, A. L.
PY - 2004
Y1 - 2004
N2 - Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea. Antidromic electrical or chemical stimulation of trigeminal sensory nerves results in neurogenic plasma extravasation in inner ear tissues. The primary aim of this study was to reveal the possible morphological basis of cochlear vascular changes mediated by capsaicin-sensitive sensory nerves. Therefore, the distribution of SP and capsaicin receptor (transient receptor potential vanilloid type 1 - TRPV1) was investigated by double immunolabeling to demonstrate the anatomical relationships between the cochlear and vertebro-basilar blood vessels and the trigeminal sensory fiber system. Extensive TRPV1 and SP expression and co-localization were observed in axons within the adventitial layer of the basilar artery, the anterior inferior cerebellar artery, the SMA, and the radiating arterioles of the cochlea. There appears to be a functional relationship between the trigeminal ganglion and the cochlear blood vessels since electrical stimulation of the trigeminal ganglion induced significant plasma extravasation from the SMA and the radiating arterioles. The findings suggest that stimulation of paravascular afferent nerves may result in permeability changes in the basilar and cochlear vascular bed and may contribute to the mechanisms of vertebro-basilar type of headache through the release of SP and stimulation of TPVR1, respectively. We propose that vertigo, tinnitus, and hearing deficits associated with migraine may arise from perturbations of capsaicin-sensitive trigeminal sensory ganglion neurons projecting to the cochlea.
AB - Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea. Antidromic electrical or chemical stimulation of trigeminal sensory nerves results in neurogenic plasma extravasation in inner ear tissues. The primary aim of this study was to reveal the possible morphological basis of cochlear vascular changes mediated by capsaicin-sensitive sensory nerves. Therefore, the distribution of SP and capsaicin receptor (transient receptor potential vanilloid type 1 - TRPV1) was investigated by double immunolabeling to demonstrate the anatomical relationships between the cochlear and vertebro-basilar blood vessels and the trigeminal sensory fiber system. Extensive TRPV1 and SP expression and co-localization were observed in axons within the adventitial layer of the basilar artery, the anterior inferior cerebellar artery, the SMA, and the radiating arterioles of the cochlea. There appears to be a functional relationship between the trigeminal ganglion and the cochlear blood vessels since electrical stimulation of the trigeminal ganglion induced significant plasma extravasation from the SMA and the radiating arterioles. The findings suggest that stimulation of paravascular afferent nerves may result in permeability changes in the basilar and cochlear vascular bed and may contribute to the mechanisms of vertebro-basilar type of headache through the release of SP and stimulation of TPVR1, respectively. We propose that vertigo, tinnitus, and hearing deficits associated with migraine may arise from perturbations of capsaicin-sensitive trigeminal sensory ganglion neurons projecting to the cochlea.
KW - AICA
KW - Anterior inferior cerebellar artery
KW - BA
KW - Basilar artery
KW - Blood pressure
KW - Bovine serum albumin
KW - BP
KW - BSA
KW - C-fibers
KW - Calcitonin gene-related peptide
KW - Capsaicin
KW - CBF
KW - CGRP
KW - CNS
KW - Cochlear blood flow
KW - Guinea-pig
KW - Headache
KW - Plasma extravasation
KW - Trigeminus
UR - http://www.scopus.com/inward/record.url?scp=1542351164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542351164&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2003.12.030
DO - 10.1016/j.neuroscience.2003.12.030
M3 - Article
C2 - 15026132
AN - SCOPUS:1542351164
VL - 124
SP - 919
EP - 927
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 4
ER -