Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries

Z. Vass, C. F. Dai, P. S. Steyger, G. Jancsó, D. R. Trune, A. L. Nuttall

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea. Antidromic electrical or chemical stimulation of trigeminal sensory nerves results in neurogenic plasma extravasation in inner ear tissues. The primary aim of this study was to reveal the possible morphological basis of cochlear vascular changes mediated by capsaicin-sensitive sensory nerves. Therefore, the distribution of SP and capsaicin receptor (transient receptor potential vanilloid type 1 - TRPV1) was investigated by double immunolabeling to demonstrate the anatomical relationships between the cochlear and vertebro-basilar blood vessels and the trigeminal sensory fiber system. Extensive TRPV1 and SP expression and co-localization were observed in axons within the adventitial layer of the basilar artery, the anterior inferior cerebellar artery, the SMA, and the radiating arterioles of the cochlea. There appears to be a functional relationship between the trigeminal ganglion and the cochlear blood vessels since electrical stimulation of the trigeminal ganglion induced significant plasma extravasation from the SMA and the radiating arterioles. The findings suggest that stimulation of paravascular afferent nerves may result in permeability changes in the basilar and cochlear vascular bed and may contribute to the mechanisms of vertebro-basilar type of headache through the release of SP and stimulation of TPVR1, respectively. We propose that vertigo, tinnitus, and hearing deficits associated with migraine may arise from perturbations of capsaicin-sensitive trigeminal sensory ganglion neurons projecting to the cochlea.

Original languageEnglish
Pages (from-to)919-927
Number of pages9
JournalNeuroscience
Volume124
Issue number4
DOIs
Publication statusPublished - 2004

Fingerprint

TRPV Cation Channels
Basilar Artery
Cochlea
Substance P
Nerve Fibers
Trigeminal Ganglion
Blood Vessels
Capsaicin
Arterioles
Arteries
Electric Stimulation
Stria Vascularis
Chemical Stimulation
Sensory Ganglia
Neurokinin-1 Receptors
Adventitia
Trigeminal Nerve
Tinnitus
Vertigo
Sensory Receptor Cells

Keywords

  • AICA
  • Anterior inferior cerebellar artery
  • BA
  • Basilar artery
  • Blood pressure
  • Bovine serum albumin
  • BP
  • BSA
  • C-fibers
  • Calcitonin gene-related peptide
  • Capsaicin
  • CBF
  • CGRP
  • CNS
  • Cochlear blood flow
  • Guinea-pig
  • Headache
  • Plasma extravasation
  • Trigeminus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries. / Vass, Z.; Dai, C. F.; Steyger, P. S.; Jancsó, G.; Trune, D. R.; Nuttall, A. L.

In: Neuroscience, Vol. 124, No. 4, 2004, p. 919-927.

Research output: Contribution to journalArticle

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T1 - Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries

AU - Vass, Z.

AU - Dai, C. F.

AU - Steyger, P. S.

AU - Jancsó, G.

AU - Trune, D. R.

AU - Nuttall, A. L.

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N2 - Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea. Antidromic electrical or chemical stimulation of trigeminal sensory nerves results in neurogenic plasma extravasation in inner ear tissues. The primary aim of this study was to reveal the possible morphological basis of cochlear vascular changes mediated by capsaicin-sensitive sensory nerves. Therefore, the distribution of SP and capsaicin receptor (transient receptor potential vanilloid type 1 - TRPV1) was investigated by double immunolabeling to demonstrate the anatomical relationships between the cochlear and vertebro-basilar blood vessels and the trigeminal sensory fiber system. Extensive TRPV1 and SP expression and co-localization were observed in axons within the adventitial layer of the basilar artery, the anterior inferior cerebellar artery, the SMA, and the radiating arterioles of the cochlea. There appears to be a functional relationship between the trigeminal ganglion and the cochlear blood vessels since electrical stimulation of the trigeminal ganglion induced significant plasma extravasation from the SMA and the radiating arterioles. The findings suggest that stimulation of paravascular afferent nerves may result in permeability changes in the basilar and cochlear vascular bed and may contribute to the mechanisms of vertebro-basilar type of headache through the release of SP and stimulation of TPVR1, respectively. We propose that vertigo, tinnitus, and hearing deficits associated with migraine may arise from perturbations of capsaicin-sensitive trigeminal sensory ganglion neurons projecting to the cochlea.

AB - Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea. Antidromic electrical or chemical stimulation of trigeminal sensory nerves results in neurogenic plasma extravasation in inner ear tissues. The primary aim of this study was to reveal the possible morphological basis of cochlear vascular changes mediated by capsaicin-sensitive sensory nerves. Therefore, the distribution of SP and capsaicin receptor (transient receptor potential vanilloid type 1 - TRPV1) was investigated by double immunolabeling to demonstrate the anatomical relationships between the cochlear and vertebro-basilar blood vessels and the trigeminal sensory fiber system. Extensive TRPV1 and SP expression and co-localization were observed in axons within the adventitial layer of the basilar artery, the anterior inferior cerebellar artery, the SMA, and the radiating arterioles of the cochlea. There appears to be a functional relationship between the trigeminal ganglion and the cochlear blood vessels since electrical stimulation of the trigeminal ganglion induced significant plasma extravasation from the SMA and the radiating arterioles. The findings suggest that stimulation of paravascular afferent nerves may result in permeability changes in the basilar and cochlear vascular bed and may contribute to the mechanisms of vertebro-basilar type of headache through the release of SP and stimulation of TPVR1, respectively. We propose that vertigo, tinnitus, and hearing deficits associated with migraine may arise from perturbations of capsaicin-sensitive trigeminal sensory ganglion neurons projecting to the cochlea.

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KW - Basilar artery

KW - Blood pressure

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KW - BSA

KW - C-fibers

KW - Calcitonin gene-related peptide

KW - Capsaicin

KW - CBF

KW - CGRP

KW - CNS

KW - Cochlear blood flow

KW - Guinea-pig

KW - Headache

KW - Plasma extravasation

KW - Trigeminus

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DO - 10.1016/j.neuroscience.2003.12.030

M3 - Article

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EP - 927

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

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