Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta

Á Kittel, Zs Csapó, É Csizmadia, S. W. Jackson, S. C. Robson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Nucleoside triphosphate diphosphohydrolase-1 (NTPD-ase1/CD39) is the dominant ecto-nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type-2 purinergic (P2) G-protein coupled receptors (GPCRs). Hence, this ectoenzyme could regulate nucleotide-mediated signalling events in placental tissue. This immunohistochemical and immuno-electron microscopic study demonstrates the expression of NTPDase1/CD39, P2Y1 and P2Y2 receptors in different cell types of human placenta. Specifically P2Y1 has an exclusive vascular distribution whereas P2Y2 is localized on trophoblastic villi. Co-localization of P2Y1 and NTPD-ase1/CD39 are observed in caveolae, membrane micro-domains of endothelial cells. The differential localization of these P2 receptors might indicate their unique roles in the regulation of extracellular nucleotide concentrations in human placental tissues and consequent effects on vascular tone and blood fluidity.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalEuropean Journal of Histochemistry
Volume48
Issue number3
Publication statusPublished - Jul 2004

Keywords

  • Caveolae
  • Caveolin
  • Endothelial cell
  • G-protein coupled receptor
  • Nucleotide signaling

ASJC Scopus subject areas

  • Biophysics
  • Histology
  • Cell Biology

Fingerprint Dive into the research topics of 'Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta'. Together they form a unique fingerprint.

  • Cite this