Co-infections with hepatitis G and TT virus in patients with chronic hepatitis C in Hungary

A. Pár, M. Takács, Judit Brojnás, G. Berencsi, Mária Paál, M. Horányi, A. Miseta, G. Hegedüs, G. Mózsik, B. Hunyady

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The significance of co-infections with novel hepatitis viruses Hepatitis G (GBV-C, HGV) and TT virus (TTV) in chronic hepatitis C is not clear. We determined the prevalence of HGV RNA and TTV DNA in chronic hepatitis C patients and in asymptomatic hepatitis C virus (HCV) carriers, and assessed the influence of these agents on the course of HCV infection. Seventy-seven patients with chronic hepatitis C - 50 of them treated with interferon (IFN) - and 33 HCV carriers with normal alanine aminotransferase have been investigated. Previous HBV infection was detected by testing serum HBsAg and aHBc. HGV RNA and TTV DNA were detected by PCR. In the healthy population, the prevalence of anti-HCV was 0.3%, HGV RNA 8.0% and TTV DNA 18.5%. In chronic hepatitis C HGV RNA occurred in 9.09% and TTV DNA in 40.25% of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20% vs. 45.7% found in non-responders. Among asymptomatic HCV-carriers, the prevalence of HGV RNA was 9.09% and TTV DNA 75.7%. Neither HGV RNA nor TTV DNA had apparent effect on the HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.

Original languageEnglish
Pages (from-to)437-447
Number of pages11
JournalActa Microbiologica et Immunologica Hungarica
Volume51
Issue number4
DOIs
Publication statusPublished - 2004

Fingerprint

Torque teno virus
GB virus C
Hungary
Chronic Hepatitis C
Coinfection
Hepacivirus
Interferons
RNA Viruses
DNA
Virus Diseases
RNA
Hepatitis B Surface Antigens
Alanine Transaminase
Hepatitis
Antiviral Agents

Keywords

  • Co-infections
  • Hepatitis C
  • HGV
  • IFN
  • TTV

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

@article{347fcf22e5db470b8b6fde21c0846b6f,
title = "Co-infections with hepatitis G and TT virus in patients with chronic hepatitis C in Hungary",
abstract = "The significance of co-infections with novel hepatitis viruses Hepatitis G (GBV-C, HGV) and TT virus (TTV) in chronic hepatitis C is not clear. We determined the prevalence of HGV RNA and TTV DNA in chronic hepatitis C patients and in asymptomatic hepatitis C virus (HCV) carriers, and assessed the influence of these agents on the course of HCV infection. Seventy-seven patients with chronic hepatitis C - 50 of them treated with interferon (IFN) - and 33 HCV carriers with normal alanine aminotransferase have been investigated. Previous HBV infection was detected by testing serum HBsAg and aHBc. HGV RNA and TTV DNA were detected by PCR. In the healthy population, the prevalence of anti-HCV was 0.3{\%}, HGV RNA 8.0{\%} and TTV DNA 18.5{\%}. In chronic hepatitis C HGV RNA occurred in 9.09{\%} and TTV DNA in 40.25{\%} of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20{\%} vs. 45.7{\%} found in non-responders. Among asymptomatic HCV-carriers, the prevalence of HGV RNA was 9.09{\%} and TTV DNA 75.7{\%}. Neither HGV RNA nor TTV DNA had apparent effect on the HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.",
keywords = "Co-infections, Hepatitis C, HGV, IFN, TTV",
author = "A. P{\'a}r and M. Tak{\'a}cs and Judit Brojn{\'a}s and G. Berencsi and M{\'a}ria Pa{\'a}l and M. Hor{\'a}nyi and A. Miseta and G. Heged{\"u}s and G. M{\'o}zsik and B. Hunyady",
year = "2004",
doi = "10.1556/AMicr.51.2004.4.4",
language = "English",
volume = "51",
pages = "437--447",
journal = "Acta Microbiologica et Immunologica Hungarica",
issn = "1217-8950",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - Co-infections with hepatitis G and TT virus in patients with chronic hepatitis C in Hungary

AU - Pár, A.

AU - Takács, M.

AU - Brojnás, Judit

AU - Berencsi, G.

AU - Paál, Mária

AU - Horányi, M.

AU - Miseta, A.

AU - Hegedüs, G.

AU - Mózsik, G.

AU - Hunyady, B.

PY - 2004

Y1 - 2004

N2 - The significance of co-infections with novel hepatitis viruses Hepatitis G (GBV-C, HGV) and TT virus (TTV) in chronic hepatitis C is not clear. We determined the prevalence of HGV RNA and TTV DNA in chronic hepatitis C patients and in asymptomatic hepatitis C virus (HCV) carriers, and assessed the influence of these agents on the course of HCV infection. Seventy-seven patients with chronic hepatitis C - 50 of them treated with interferon (IFN) - and 33 HCV carriers with normal alanine aminotransferase have been investigated. Previous HBV infection was detected by testing serum HBsAg and aHBc. HGV RNA and TTV DNA were detected by PCR. In the healthy population, the prevalence of anti-HCV was 0.3%, HGV RNA 8.0% and TTV DNA 18.5%. In chronic hepatitis C HGV RNA occurred in 9.09% and TTV DNA in 40.25% of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20% vs. 45.7% found in non-responders. Among asymptomatic HCV-carriers, the prevalence of HGV RNA was 9.09% and TTV DNA 75.7%. Neither HGV RNA nor TTV DNA had apparent effect on the HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.

AB - The significance of co-infections with novel hepatitis viruses Hepatitis G (GBV-C, HGV) and TT virus (TTV) in chronic hepatitis C is not clear. We determined the prevalence of HGV RNA and TTV DNA in chronic hepatitis C patients and in asymptomatic hepatitis C virus (HCV) carriers, and assessed the influence of these agents on the course of HCV infection. Seventy-seven patients with chronic hepatitis C - 50 of them treated with interferon (IFN) - and 33 HCV carriers with normal alanine aminotransferase have been investigated. Previous HBV infection was detected by testing serum HBsAg and aHBc. HGV RNA and TTV DNA were detected by PCR. In the healthy population, the prevalence of anti-HCV was 0.3%, HGV RNA 8.0% and TTV DNA 18.5%. In chronic hepatitis C HGV RNA occurred in 9.09% and TTV DNA in 40.25% of cases. In IFN-treated patients with sustained remission, the frequency of TTV was 20% vs. 45.7% found in non-responders. Among asymptomatic HCV-carriers, the prevalence of HGV RNA was 9.09% and TTV DNA 75.7%. Neither HGV RNA nor TTV DNA had apparent effect on the HCV infection. TTV was detected with the lowest frequency in persons with sustained remission due to IFN, suggesting antiviral effect of IFN on TTV.

KW - Co-infections

KW - Hepatitis C

KW - HGV

KW - IFN

KW - TTV

UR - http://www.scopus.com/inward/record.url?scp=19944427186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944427186&partnerID=8YFLogxK

U2 - 10.1556/AMicr.51.2004.4.4

DO - 10.1556/AMicr.51.2004.4.4

M3 - Article

C2 - 15704332

AN - SCOPUS:19944427186

VL - 51

SP - 437

EP - 447

JO - Acta Microbiologica et Immunologica Hungarica

JF - Acta Microbiologica et Immunologica Hungarica

SN - 1217-8950

IS - 4

ER -