Co-infection with coxsackievirus A5 and norovirus GII.4 could have been the trigger of the first episode of severe acute encephalopathy in a six-year-old child with the intermittent form of maple syrup urine disease (MSUD)

Ákos Boros, P. Pankovics, Sándor Kőmíves, Zoltán Liptai, Sarolta Dobner, Enikő Ujhelyi, György Várallyay, Petra Zsidegh, Nóra Bolba, G. Reuter

Research output: Contribution to journalArticle

Abstract

In this case study, a co-infection with coxsackievirus A5 (family Picornaviridae) and norovirus GII.4 (family Caliciviridae) was detected by RT-PCR in a faecal sample from a six-year-old girl with symptoms of severe acute encephalopathy subsequently diagnosed as the intermittent form of maple syrup urine disease (MSUD). The two co-infecting viruses, which had been detected previously, appeared to have triggered the underlying metabolic disorder. Here, we describe the genotyping of the viruses, as well as the chronological course, laboratory test results, and clinical presentation of this case, which included recurrent vomiting without diarrhoea, metabolic acidosis, unconsciousness, seizure and circulatory collapse, but with a positive final outcome.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalArchives of Virology
DOIs
Publication statusAccepted/In press - Feb 27 2017

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Maple Syrup Urine Disease
Norovirus
Enterovirus
Brain Diseases
Coinfection
Caliciviridae
Viruses
Picornaviridae
Unconsciousness
Acidosis
Vomiting
Diarrhea
Shock
Seizures
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Virology

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Co-infection with coxsackievirus A5 and norovirus GII.4 could have been the trigger of the first episode of severe acute encephalopathy in a six-year-old child with the intermittent form of maple syrup urine disease (MSUD). / Boros, Ákos; Pankovics, P.; Kőmíves, Sándor; Liptai, Zoltán; Dobner, Sarolta; Ujhelyi, Enikő; Várallyay, György; Zsidegh, Petra; Bolba, Nóra; Reuter, G.

In: Archives of Virology, 27.02.2017, p. 1-7.

Research output: Contribution to journalArticle

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