Co-expression of vascular endothelial growth factor and its receptor flt-1 in malignant pleural mesothelioma

Jens Ekkehard König, E. Tolnay, Thorsten Wiethege, Klaus Michael Müller

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Vascular endothelial growth factor (VEGF) is a potent angiogenic protein with a selective mitogenic effect on endothelial cells known to be involved in many normal and pathological processes. Coexpression of VEGF and its receptor flt-1 has been reported in different types of malignant tumors. Objective: In the present study we investigated the expression of VEGF and flt-1 in 90 cases of diffuse malignant pleural mesotheliomas. Methods: VEGF and flt-1 expression was analyzed by immunohistochemistry and non-radioactive in situ hybridization. Results: VEGF expression was visualized immunohistochemically in tumor cells. flt-1 expression correlated with histological differentiation (p <0.013). Furthermore, expression of flt-1 was detected in tumor cells, macrophages and microvessels adjacent to tumor cells. VEGF and flt-1 expression were confirmed by in situ hybridization. Conclusion: There was a statistically significant correlation between VEGF and flt-1 expression (p <0.001). The observed coexpression of VEGF and flt-1 possibly suggests a potential autocrine loop for malignant pleural mesothelioma cells. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalRespiration
Volume67
Issue number1
Publication statusPublished - 2000

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Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor A
In Situ Hybridization
Neoplasms
Angiogenic Proteins
Pathologic Processes
Microvessels
Malignant Mesothelioma
Endothelial Cells
Immunohistochemistry
Macrophages

Keywords

  • Diffuse malignant mesothelioma
  • flt-1 receptor
  • Histological differentiation
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Co-expression of vascular endothelial growth factor and its receptor flt-1 in malignant pleural mesothelioma. / König, Jens Ekkehard; Tolnay, E.; Wiethege, Thorsten; Müller, Klaus Michael.

In: Respiration, Vol. 67, No. 1, 2000, p. 36-40.

Research output: Contribution to journalArticle

König, Jens Ekkehard ; Tolnay, E. ; Wiethege, Thorsten ; Müller, Klaus Michael. / Co-expression of vascular endothelial growth factor and its receptor flt-1 in malignant pleural mesothelioma. In: Respiration. 2000 ; Vol. 67, No. 1. pp. 36-40.
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