Co-expression of c-abl and c-myb oncogenes in Philadelphia chromosome-negative, bcr-negative chronic myeloid Leukaemia

F. Tóth, Jolán Kiss, Attila Kiss, Béla Telek, E. Oláh, János Iványi, Kalman Rak

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Three cases of Philadelphia (Ph) chromosome-negative, bcr-negative chronic myeloid leukaemia (CML) have been investigated for oncogene expression by Northern blot and cytoplasmic RNA dot blot hybridization. Considerably high levels of expression of c-abl and c-myb were observed in all cases. In the Ph-negative cells the normal 6.0 and 7.0 kb c-abl and 3.8 kb c-myb transcripts were found. No amplification of c-abl or c-myb oncogenes was detected in the DNAs of Ph-negative CML cells. Data suggest that co-operation between the overexpressed c-abl and c-myb oncogenes is causally related to Ph-negative, bcr-negative CML.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalLeukemia Research
Volume18
Issue number5
DOIs
Publication statusPublished - 1994

Fingerprint

myb Genes
Philadelphia Chromosome
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Myeloid Cells
Oncogenes
Northern Blotting
RNA
DNA

Keywords

  • bcr-negative CML
  • c-myb
  • Human c-abl
  • Ph-negative

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Co-expression of c-abl and c-myb oncogenes in Philadelphia chromosome-negative, bcr-negative chronic myeloid Leukaemia. / Tóth, F.; Kiss, Jolán; Kiss, Attila; Telek, Béla; Oláh, E.; Iványi, János; Rak, Kalman.

In: Leukemia Research, Vol. 18, No. 5, 1994, p. 373-380.

Research output: Contribution to journalArticle

Tóth, F. ; Kiss, Jolán ; Kiss, Attila ; Telek, Béla ; Oláh, E. ; Iványi, János ; Rak, Kalman. / Co-expression of c-abl and c-myb oncogenes in Philadelphia chromosome-negative, bcr-negative chronic myeloid Leukaemia. In: Leukemia Research. 1994 ; Vol. 18, No. 5. pp. 373-380.
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