Clozapine in the treatment of pregnant schizophrenic women

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The treatment of schizophrenia during pregnancy means an increased risk for both the mother and fetus. Serious problems may arise in case a pregnant psychotic woman does not get adequate pharmacotherapy. The use of antipsychotics during pregnancy, however, may mean an increased risk for the fetus. An atypical neuroleptic drug, clozapine, offers clear benefits to many treatment-resistant schizophrenic patients, as it does not cause extrapyramidal side effects, and does not increase the serum prolactin level. With careful monitoring of hematologic parameters, the occurrence of leukopenia can be avoided. It is important that clozapine - according to a limited number of case studies - can be used during pregnancy without any known adverse effect on the newborns, while there are some other information warranting more cautious approach. We present data of four schizophrenic women with a total of six pregnancies during clozapine treatment, one of them three times, who gave birth to healthy children. We discuss the role of clozapine as an alternative agent in the treatment of pregnant schizophrenic women.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalPsychiatria Danubina
Issue number1
Publication statusPublished - Mar 1 1998



  • Clozapine
  • Pregnancy
  • Treatment of schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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