Cloning of rabbit uricase cDNA reveals a conserved carboxy-terminal tripeptide in three species

Kiyoto Motojima, Sataro Goto

Research output: Contribution to journalArticle

10 Citations (Scopus)


cDNA clones encoding uricase have been isolated from a rabbit liver cDNA library. The nucleotide sequences of the cDNAs have been determined and those of the rat uricase cDNA have been revised. In all three uricases, the carboxy-terminal tripeptides are Ser-Arg/Lys-Leu sequences, which have recently been suggested as an essential element of peroxisomal targetting signals for many but not all peroxisomal proteins.

Original languageEnglish
Pages (from-to)116-118
Number of pages3
JournalBBA - Gene Structure and Expression
Issue number1
Publication statusPublished - Jun 1 1989



  • (Rabbit liver)
  • Nucleotide sequence
  • Peroxisomal targeting signal
  • Uricase

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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