Cloning of a novel testis specific protein serine/threonine phosphatase, PPN 58A, from Drosophila melanogaster

Christopher G. Armstrong, Viktor Dombradi, David J. Mann, Patricia T.W. Cohen

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11 Citations (Scopus)

Abstract

A gene encoding a novel member of the PPP family of protein serine/threonine phosphatases, termed PPN 58A, was cloned from Drosophila melanogaster. The deduced amino acid sequence of PPN 58A exhibits 59-62% identity to D. melanogaster PP1 isoforms, 51% identity to D. melanogaster PPY 55A and ≤40% identity to other members of the PPP family. The single copy gene PPN 58A maps to chromosome 2 locus 58A. Analysis of PPN 58A mRNA reveals that, like PPY 55A, PPN 58A is a testis specific enzyme.

Original languageEnglish
Pages (from-to)234-238
Number of pages5
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1399
Issue number2-3
DOIs
Publication statusPublished - Aug 20 1998

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Keywords

  • (Drosophila)
  • Gene localisation
  • Gene sequence
  • Protein phosphatase
  • Testis

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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