Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer

Friederike Müller-Pillasch, Christine Wallrapp, Katrin Bartels, Gabor Varga, Helmut Friess, Markus Büchler, Guido Adler, Thomas M. Gress

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In a previous large scale screen for differentially expressed genes in pancreatic cancer, we identified a gene highly overexpressed in cancer encoding a novel putative transmembrane protein with two Kunitz-type serine protease inhibitor domains. The identified gene named kop (Kunitz domain containing protein overexpressed in pancreatic cancer) was assigned to chromosome 19 in the region 19q13.1. Kop was detected at high levels in pancreatic cancer cell lines and was overexpressed in pancreatic cancer tissues as compared to both, normal pancreas and chronic pancreatitis tissues. Being a member of the Kunitz-type serine protease inhibitor family, this new gene may participate in tumour cell invasion and metastasis and in the development of the marked desmoplastic reaction typical for human pancreatic cancer tissues. In this context, the fact that kop has a putative transmembrane domain may have functional implications of particular interest.

Original languageEnglish
Pages (from-to)88-95
Number of pages8
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1395
Issue number1
DOIs
Publication statusPublished - Jan 7 1998

Keywords

  • Extracellular matrix
  • Kunitz-domain
  • Pancreatic cancer
  • Serpin
  • Trypsin inhibitor

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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