Cloned antigens and antiidiotypes

D. Herlyn, R. Somasundaram, J. Zaloudik, W. Li, L. Jacob, D. Harris, M. P. Kieny -, R. Ricciardi, E. Gonczol, H. Sears, M. Mastrangelo

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5 Citations (Scopus)

Abstract

Both monoclonal and polyclonal antiidiotypic antibodies mimicking the human colorectal carcinoma (CRC) associated antigen CO17-1A/GA733 have induced antigen-specific humoral and cellular immunity in CRC patients. The immune responses may underlie the clinical responses observed in some of the treated patients. Recently, the CO17-1A/GA733 antigen has been molecularly cloned and expressed in baculo-, adeno-, and vaccinia viruses. In preclinical studies, these recombinant antigen preparations elicited specific humoral immunity (cytotoxic antibodies) and cellular immunity (DTH-reactive and proliferative T cells). Antibody titers elicited in animals by recombinant antigen were significantly higher than those elicited by antiidiotypes. The recombinant antigen has a potential as a vaccine for CRC patients.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalHybridoma
Volume14
Issue number2
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Immunology
  • Genetics

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    Herlyn, D., Somasundaram, R., Zaloudik, J., Li, W., Jacob, L., Harris, D., Kieny -, M. P., Ricciardi, R., Gonczol, E., Sears, H., & Mastrangelo, M. (1995). Cloned antigens and antiidiotypes. Hybridoma, 14(2), 159-166. https://doi.org/10.1089/hyb.1995.14.159