Clink, a nanovirus-encoded protein, binds both pRB and SKP1

Marie N. Aronson, Alain D. Meyer, J. Györgyey, Lina Katul, H. Josef Vetten, Bruno Gronenborn, Tatiana Timchenko

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Clink, a 20-kDa protein of faba bean necrotic yellows virus, a single- stranded DNA plant virus, interacts with pRB family members and a SKP1 homologue from Medicago sativa. An LxCxE motif and an F-box of Clink mediate the interactions with the respective proteins. The capacity of Clink to bind pRB correlates with its ability to stimulate viral replication. Interaction of a single protein with the cell cycle regulator pRB and SKP1, a constituent of the ubiquitin-protein turnover pathway, appears to be a novel feature. Hence, Clink may represent a new class of viral cell cycle modulators.

Original languageEnglish
Pages (from-to)2967-2972
Number of pages6
JournalJournal of Virology
Volume74
Issue number7
DOIs
Publication statusPublished - 2000

Fingerprint

Nanovirus
Faba bean necrotic yellows virus
cell cycle
F-Box Motifs
Cell Cycle
single-stranded DNA
Proteins
proteins
plant viruses
ubiquitin
virus replication
protein metabolism
Medicago sativa
Vicia faba
Plant Viruses
Aptitude
DNA Viruses
Single-Stranded DNA
Ubiquitin
Viruses

ASJC Scopus subject areas

  • Immunology

Cite this

Aronson, M. N., Meyer, A. D., Györgyey, J., Katul, L., Vetten, H. J., Gronenborn, B., & Timchenko, T. (2000). Clink, a nanovirus-encoded protein, binds both pRB and SKP1. Journal of Virology, 74(7), 2967-2972. https://doi.org/10.1128/JVI.74.7.2967-2972.2000

Clink, a nanovirus-encoded protein, binds both pRB and SKP1. / Aronson, Marie N.; Meyer, Alain D.; Györgyey, J.; Katul, Lina; Vetten, H. Josef; Gronenborn, Bruno; Timchenko, Tatiana.

In: Journal of Virology, Vol. 74, No. 7, 2000, p. 2967-2972.

Research output: Contribution to journalArticle

Aronson, MN, Meyer, AD, Györgyey, J, Katul, L, Vetten, HJ, Gronenborn, B & Timchenko, T 2000, 'Clink, a nanovirus-encoded protein, binds both pRB and SKP1', Journal of Virology, vol. 74, no. 7, pp. 2967-2972. https://doi.org/10.1128/JVI.74.7.2967-2972.2000
Aronson, Marie N. ; Meyer, Alain D. ; Györgyey, J. ; Katul, Lina ; Vetten, H. Josef ; Gronenborn, Bruno ; Timchenko, Tatiana. / Clink, a nanovirus-encoded protein, binds both pRB and SKP1. In: Journal of Virology. 2000 ; Vol. 74, No. 7. pp. 2967-2972.
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