Clinicopathological changes and effect of imidocarb therapy in dogs experimentally infected with Babesia canis

Ákos Máthé, K. Vörös, T. Németh, I. Biksi, Cs Hetyey, F. Manczur, L. Tekes

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In this study one spleen-intact dog (A) and two splenectomised dogs (BSE, CSE) were infected with Babesia canis. All animals developed an acute disease characterised by fever, haemoglobinuria and anaemia, the latter being more severe in the splenectomised dogs. Fever and parasitised red blood cells were detected for three days after imidocarb treatment in the splenectomised animals. Haematological abnormalities included regenerative anaemia, thrombocytopenia and leukopenia (due to neutropenia and lymphopenia) in the acute phase, soon followed by leukocytosis, neutrophilia and left shift a few days later. Acute hepatopathy was detected in all dogs with elevated ALT activity, which was more seriously altered in the splenectomised dogs. Diffuse changes in liver structure and hepatomegaly were seen by ultrasonography. Liver biopsy and histology revealed acute, non-purulent hepatitis in the splenectomised dogs. Both splenectomised dogs were successfully cured after collection of 400 ml highly parasitised blood, proving that large-amount antigen production is possible with rescuing the experimental animals. Whole blood transfusion, imidocarb and supportive care with infusions, antipyretics, glucocorticoids and diuretics were applied. The spleen-intact dog clinically recovered after receiving supportive treatment, with no imidocarb therapy. Microbial infections developed in both splenectomised animals (BSE: haemobartonellosis, CSE: osteomyelitis caused by Escherichia coli), probably as a consequence of immunosuppression after splenectomy and glucocorticoid therapy.

Original languageEnglish
Pages (from-to)19-33
Number of pages15
JournalActa Veterinaria Hungarica
Volume54
Issue number1
DOIs
Publication statusPublished - 2006

Fingerprint

Imidocarb
imidocarb
Babesia canis
therapy dogs
Babesia
Dogs
dogs
Therapeutics
glucocorticoids
anemia
Anaplasmataceae Infections
Glucocorticoids
fever
Anemia
spleen
Fever
Spleen
Hemoglobinuria
hemoglobinuria
antipyretics

Keywords

  • Babesia canis
  • Babesiosis
  • Clinicopathology
  • Dog
  • Experimental
  • Imidocarb

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Clinicopathological changes and effect of imidocarb therapy in dogs experimentally infected with Babesia canis. / Máthé, Ákos; Vörös, K.; Németh, T.; Biksi, I.; Hetyey, Cs; Manczur, F.; Tekes, L.

In: Acta Veterinaria Hungarica, Vol. 54, No. 1, 2006, p. 19-33.

Research output: Contribution to journalArticle

Máthé, Ákos ; Vörös, K. ; Németh, T. ; Biksi, I. ; Hetyey, Cs ; Manczur, F. ; Tekes, L. / Clinicopathological changes and effect of imidocarb therapy in dogs experimentally infected with Babesia canis. In: Acta Veterinaria Hungarica. 2006 ; Vol. 54, No. 1. pp. 19-33.
@article{265d27a305f04d91b9eec8b7e7f86453,
title = "Clinicopathological changes and effect of imidocarb therapy in dogs experimentally infected with Babesia canis",
abstract = "In this study one spleen-intact dog (A) and two splenectomised dogs (BSE, CSE) were infected with Babesia canis. All animals developed an acute disease characterised by fever, haemoglobinuria and anaemia, the latter being more severe in the splenectomised dogs. Fever and parasitised red blood cells were detected for three days after imidocarb treatment in the splenectomised animals. Haematological abnormalities included regenerative anaemia, thrombocytopenia and leukopenia (due to neutropenia and lymphopenia) in the acute phase, soon followed by leukocytosis, neutrophilia and left shift a few days later. Acute hepatopathy was detected in all dogs with elevated ALT activity, which was more seriously altered in the splenectomised dogs. Diffuse changes in liver structure and hepatomegaly were seen by ultrasonography. Liver biopsy and histology revealed acute, non-purulent hepatitis in the splenectomised dogs. Both splenectomised dogs were successfully cured after collection of 400 ml highly parasitised blood, proving that large-amount antigen production is possible with rescuing the experimental animals. Whole blood transfusion, imidocarb and supportive care with infusions, antipyretics, glucocorticoids and diuretics were applied. The spleen-intact dog clinically recovered after receiving supportive treatment, with no imidocarb therapy. Microbial infections developed in both splenectomised animals (BSE: haemobartonellosis, CSE: osteomyelitis caused by Escherichia coli), probably as a consequence of immunosuppression after splenectomy and glucocorticoid therapy.",
keywords = "Babesia canis, Babesiosis, Clinicopathology, Dog, Experimental, Imidocarb",
author = "{\'A}kos M{\'a}th{\'e} and K. V{\"o}r{\"o}s and T. N{\'e}meth and I. Biksi and Cs Hetyey and F. Manczur and L. Tekes",
year = "2006",
doi = "10.1556/AVet.54.2006.1.3",
language = "English",
volume = "54",
pages = "19--33",
journal = "Acta Veterinaria Hungarica",
issn = "0236-6290",
publisher = "Akademiai Kiado",
number = "1",

}

TY - JOUR

T1 - Clinicopathological changes and effect of imidocarb therapy in dogs experimentally infected with Babesia canis

AU - Máthé, Ákos

AU - Vörös, K.

AU - Németh, T.

AU - Biksi, I.

AU - Hetyey, Cs

AU - Manczur, F.

AU - Tekes, L.

PY - 2006

Y1 - 2006

N2 - In this study one spleen-intact dog (A) and two splenectomised dogs (BSE, CSE) were infected with Babesia canis. All animals developed an acute disease characterised by fever, haemoglobinuria and anaemia, the latter being more severe in the splenectomised dogs. Fever and parasitised red blood cells were detected for three days after imidocarb treatment in the splenectomised animals. Haematological abnormalities included regenerative anaemia, thrombocytopenia and leukopenia (due to neutropenia and lymphopenia) in the acute phase, soon followed by leukocytosis, neutrophilia and left shift a few days later. Acute hepatopathy was detected in all dogs with elevated ALT activity, which was more seriously altered in the splenectomised dogs. Diffuse changes in liver structure and hepatomegaly were seen by ultrasonography. Liver biopsy and histology revealed acute, non-purulent hepatitis in the splenectomised dogs. Both splenectomised dogs were successfully cured after collection of 400 ml highly parasitised blood, proving that large-amount antigen production is possible with rescuing the experimental animals. Whole blood transfusion, imidocarb and supportive care with infusions, antipyretics, glucocorticoids and diuretics were applied. The spleen-intact dog clinically recovered after receiving supportive treatment, with no imidocarb therapy. Microbial infections developed in both splenectomised animals (BSE: haemobartonellosis, CSE: osteomyelitis caused by Escherichia coli), probably as a consequence of immunosuppression after splenectomy and glucocorticoid therapy.

AB - In this study one spleen-intact dog (A) and two splenectomised dogs (BSE, CSE) were infected with Babesia canis. All animals developed an acute disease characterised by fever, haemoglobinuria and anaemia, the latter being more severe in the splenectomised dogs. Fever and parasitised red blood cells were detected for three days after imidocarb treatment in the splenectomised animals. Haematological abnormalities included regenerative anaemia, thrombocytopenia and leukopenia (due to neutropenia and lymphopenia) in the acute phase, soon followed by leukocytosis, neutrophilia and left shift a few days later. Acute hepatopathy was detected in all dogs with elevated ALT activity, which was more seriously altered in the splenectomised dogs. Diffuse changes in liver structure and hepatomegaly were seen by ultrasonography. Liver biopsy and histology revealed acute, non-purulent hepatitis in the splenectomised dogs. Both splenectomised dogs were successfully cured after collection of 400 ml highly parasitised blood, proving that large-amount antigen production is possible with rescuing the experimental animals. Whole blood transfusion, imidocarb and supportive care with infusions, antipyretics, glucocorticoids and diuretics were applied. The spleen-intact dog clinically recovered after receiving supportive treatment, with no imidocarb therapy. Microbial infections developed in both splenectomised animals (BSE: haemobartonellosis, CSE: osteomyelitis caused by Escherichia coli), probably as a consequence of immunosuppression after splenectomy and glucocorticoid therapy.

KW - Babesia canis

KW - Babesiosis

KW - Clinicopathology

KW - Dog

KW - Experimental

KW - Imidocarb

UR - http://www.scopus.com/inward/record.url?scp=30944451563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30944451563&partnerID=8YFLogxK

U2 - 10.1556/AVet.54.2006.1.3

DO - 10.1556/AVet.54.2006.1.3

M3 - Article

C2 - 16613023

AN - SCOPUS:30944451563

VL - 54

SP - 19

EP - 33

JO - Acta Veterinaria Hungarica

JF - Acta Veterinaria Hungarica

SN - 0236-6290

IS - 1

ER -