A Binswanger-betegség tünettana, kórszövettana és elkülönítése.

Translated title of the contribution: Clinico-pathology and differential diagnosis of Binswanger's disease

T. Kovács, I. Szirmai, Mátyás Papp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pathologically, Binswanger's disease is subcortical periventricular leucoencephalopathy sparing the U fibers. Clinically it is characterised by executive dysfunction, gait problems, urinary incontinence, pseudobulbar palsy, mood disturbances and dementia. The pathomechanism of Binswanger's disease is unclear. It is hypothesized that it results from an ischemic-hypoxic injury of the periventricular white matter, which, in turn, can be caused by a sclerotic elongation of the medullary arteries, widening of the perivascular spaces or decreased brain perfusion due to hypotension or heart disease. The symptoms of Binswanger's disease frequently overlap with those of normal pressure hydrocephalus, vascular parkinsonism and Alzheimer's disease. A diagnostic criterion of Binswanger's disease is radiologically demonstrated leukoaraiosis, which, on the other hand, is not equivalent with Binswanger's disease. A good clinical response after lumbar puncture or shunt implantation might lead to confusion with normal pressure hydrocephalus, which further complicates the clinical diagnosis. It is likely that among the above mentioned disorders there are a number of transitional forms and overlaps, which might be explained by the common pathomechanism of disturbance in cerebrospinal fluid circulation.

Original languageHungarian
Pages (from-to)78-87
Number of pages10
JournalIdeggyógyászati szemle
Volume58
Issue number3-4
Publication statusPublished - Mar 20 2005

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Vascular Dementia
Differential Diagnosis
Pathology
Normal Pressure Hydrocephalus
Pseudobulbar Palsy
Leukoaraiosis
Spinal Puncture
Urinary Incontinence
Parkinsonian Disorders
Gait
Vascular Diseases
Hypotension
Cerebrospinal Fluid
Dementia
Heart Diseases
Alzheimer Disease
Arteries
Perfusion
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A Binswanger-betegség tünettana, kórszövettana és elkülönítése. / Kovács, T.; Szirmai, I.; Papp, Mátyás.

In: Ideggyógyászati szemle, Vol. 58, No. 3-4, 20.03.2005, p. 78-87.

Research output: Contribution to journalArticle

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