Clinically relevant subgroups in COPD and asthma

Alice M. Turner, Lilla Tamasi, Florence Schleich, Mehmet Hoxha, Ildiko Horvath, Renaud Louis, Neil Barnes

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

As knowledge of airways disease has grown, it has become apparent that neither chronic obstructive pulmonary disease (COPD) nor asthma is a simple, easily defined disease. In the past, treatment options for both diseases were limited; thus, there was less need to define subgroups. As treatment options have grown, so has our need to predict who will respond to new drugs. To date, identifying subgroups has been largely reported by detailed clinical characterisation or differences in pathobiology. These subgroups are commonly called “phenotypes”; however, the problem of defining what constitutes a phenotype, whether this should include comorbid diseases and how to handle changes over time has led to the term being used loosely. In this review, we describe subgroups of COPD and asthma patients whose clinical characteristics we believe have therapeutic or major prognostic implications specific to the lung, and whether these subgroups are constant over time. Finally, we will discuss whether the subgroups we describe are common to both asthma and COPD, and give some examples of how treatment might be tailored in patients where the subgroup is clear, but the label of asthma or COPD is not.

Original languageEnglish
Pages (from-to)283-298
Number of pages16
JournalEuropean Respiratory Review
Volume24
Issue number136
DOIs
Publication statusPublished - Jun 1 2015

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Turner, A. M., Tamasi, L., Schleich, F., Hoxha, M., Horvath, I., Louis, R., & Barnes, N. (2015). Clinically relevant subgroups in COPD and asthma. European Respiratory Review, 24(136), 283-298. https://doi.org/10.1183/16000617.00009014