Abstract
Objective. Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as a potential biomarker for the assessment of the severity of vascular involvement. Methods. One hundred and sixty-eight consecutive SSc patients-62 with dcSSc and 106 with lcSSc-were investigated at baseline and after 1-year of follow-up. Measurements in 93 patients with primary RP and 40 healthy subjects served as controls. Results. The median RDW value of patients with SSc was higher [14.2% (25th-75th percentiles 13.5-14.8%) compared with the group of primary RP patients [13.9% (13.4-14.4%); P5% during follow-up was associated with an average 8.9% decrease in left ventricular ejection fraction (LVEF) and 7% in DLCO and these associations were independent of each other. Conclusion. RDW in SSc may represent an integrative measure of multiple pathological processes including extensive vasculopathy, fibrosis or ongoing inflammation. An increase in RDW may indicate an impairment of cardiorespiratory function.
| Original language | English |
|---|---|
| Article number | keu022 |
| Pages (from-to) | 1439-1445 |
| Number of pages | 7 |
| Journal | Rheumatology |
| Volume | 53 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Inflammation
- Left ventricular ejection fraction
- Lung fibrosis
- RDW
- Red blood cell distribution width
- Systemic sclerosis
- Vasculopathy
ASJC Scopus subject areas
- Rheumatology
- Pharmacology (medical)
Cite this
Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis. / Farkas, Nelli; Szabó, Andrea; Lóránd, Veronika; Péter Sarlós, Donát; Minier, Tünde; Prohászka, Z.; Czirják, L.; Varjú, Cecília.
In: Rheumatology, Vol. 53, No. 8, keu022, 2014, p. 1439-1445.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis
AU - Farkas, Nelli
AU - Szabó, Andrea
AU - Lóránd, Veronika
AU - Péter Sarlós, Donát
AU - Minier, Tünde
AU - Prohászka, Z.
AU - Czirják, L.
AU - Varjú, Cecília
PY - 2014
Y1 - 2014
N2 - Objective. Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as a potential biomarker for the assessment of the severity of vascular involvement. Methods. One hundred and sixty-eight consecutive SSc patients-62 with dcSSc and 106 with lcSSc-were investigated at baseline and after 1-year of follow-up. Measurements in 93 patients with primary RP and 40 healthy subjects served as controls. Results. The median RDW value of patients with SSc was higher [14.2% (25th-75th percentiles 13.5-14.8%) compared with the group of primary RP patients [13.9% (13.4-14.4%); P5% during follow-up was associated with an average 8.9% decrease in left ventricular ejection fraction (LVEF) and 7% in DLCO and these associations were independent of each other. Conclusion. RDW in SSc may represent an integrative measure of multiple pathological processes including extensive vasculopathy, fibrosis or ongoing inflammation. An increase in RDW may indicate an impairment of cardiorespiratory function.
AB - Objective. Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as a potential biomarker for the assessment of the severity of vascular involvement. Methods. One hundred and sixty-eight consecutive SSc patients-62 with dcSSc and 106 with lcSSc-were investigated at baseline and after 1-year of follow-up. Measurements in 93 patients with primary RP and 40 healthy subjects served as controls. Results. The median RDW value of patients with SSc was higher [14.2% (25th-75th percentiles 13.5-14.8%) compared with the group of primary RP patients [13.9% (13.4-14.4%); P5% during follow-up was associated with an average 8.9% decrease in left ventricular ejection fraction (LVEF) and 7% in DLCO and these associations were independent of each other. Conclusion. RDW in SSc may represent an integrative measure of multiple pathological processes including extensive vasculopathy, fibrosis or ongoing inflammation. An increase in RDW may indicate an impairment of cardiorespiratory function.
KW - Inflammation
KW - Left ventricular ejection fraction
KW - Lung fibrosis
KW - RDW
KW - Red blood cell distribution width
KW - Systemic sclerosis
KW - Vasculopathy
UR - http://www.scopus.com/inward/record.url?scp=84904886141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904886141&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/keu022
DO - 10.1093/rheumatology/keu022
M3 - Article
C2 - 24659752
AN - SCOPUS:84904886141
VL - 53
SP - 1439
EP - 1445
JO - Rheumatology
JF - Rheumatology
SN - 1462-0324
IS - 8
M1 - keu022
ER -