Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis

Nelli Farkas, Andrea Szabó, Veronika Lóránd, Donát Péter Sarlós, Tünde Minier, Z. Prohászka, L. Czirják, Cecília Varjú

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective. Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as a potential biomarker for the assessment of the severity of vascular involvement. Methods. One hundred and sixty-eight consecutive SSc patients-62 with dcSSc and 106 with lcSSc-were investigated at baseline and after 1-year of follow-up. Measurements in 93 patients with primary RP and 40 healthy subjects served as controls. Results. The median RDW value of patients with SSc was higher [14.2% (25th-75th percentiles 13.5-14.8%) compared with the group of primary RP patients [13.9% (13.4-14.4%); P5% during follow-up was associated with an average 8.9% decrease in left ventricular ejection fraction (LVEF) and 7% in DLCO and these associations were independent of each other. Conclusion. RDW in SSc may represent an integrative measure of multiple pathological processes including extensive vasculopathy, fibrosis or ongoing inflammation. An increase in RDW may indicate an impairment of cardiorespiratory function.

Original languageEnglish
Article numberkeu022
Pages (from-to)1439-1445
Number of pages7
JournalRheumatology
Volume53
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Erythrocyte Indices
Systemic Scleroderma
Erythrocytes
Biomarkers
Pathologic Processes
Cell Size
Stroke Volume
Blood Vessels
Healthy Volunteers
Fibrosis
Inflammation

Keywords

  • Inflammation
  • Left ventricular ejection fraction
  • Lung fibrosis
  • RDW
  • Red blood cell distribution width
  • Systemic sclerosis
  • Vasculopathy

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Farkas, N., Szabó, A., Lóránd, V., Péter Sarlós, D., Minier, T., Prohászka, Z., ... Varjú, C. (2014). Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis. Rheumatology, 53(8), 1439-1445. [keu022]. https://doi.org/10.1093/rheumatology/keu022

Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis. / Farkas, Nelli; Szabó, Andrea; Lóránd, Veronika; Péter Sarlós, Donát; Minier, Tünde; Prohászka, Z.; Czirják, L.; Varjú, Cecília.

In: Rheumatology, Vol. 53, No. 8, keu022, 2014, p. 1439-1445.

Research output: Contribution to journalArticle

Farkas, N, Szabó, A, Lóránd, V, Péter Sarlós, D, Minier, T, Prohászka, Z, Czirják, L & Varjú, C 2014, 'Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis', Rheumatology, vol. 53, no. 8, keu022, pp. 1439-1445. https://doi.org/10.1093/rheumatology/keu022
Farkas, Nelli ; Szabó, Andrea ; Lóránd, Veronika ; Péter Sarlós, Donát ; Minier, Tünde ; Prohászka, Z. ; Czirják, L. ; Varjú, Cecília. / Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis. In: Rheumatology. 2014 ; Vol. 53, No. 8. pp. 1439-1445.
@article{fde30b22100848c38d4eb943233f7eba,
title = "Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis",
abstract = "Objective. Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as a potential biomarker for the assessment of the severity of vascular involvement. Methods. One hundred and sixty-eight consecutive SSc patients-62 with dcSSc and 106 with lcSSc-were investigated at baseline and after 1-year of follow-up. Measurements in 93 patients with primary RP and 40 healthy subjects served as controls. Results. The median RDW value of patients with SSc was higher [14.2{\%} (25th-75th percentiles 13.5-14.8{\%}) compared with the group of primary RP patients [13.9{\%} (13.4-14.4{\%}); P5{\%} during follow-up was associated with an average 8.9{\%} decrease in left ventricular ejection fraction (LVEF) and 7{\%} in DLCO and these associations were independent of each other. Conclusion. RDW in SSc may represent an integrative measure of multiple pathological processes including extensive vasculopathy, fibrosis or ongoing inflammation. An increase in RDW may indicate an impairment of cardiorespiratory function.",
keywords = "Inflammation, Left ventricular ejection fraction, Lung fibrosis, RDW, Red blood cell distribution width, Systemic sclerosis, Vasculopathy",
author = "Nelli Farkas and Andrea Szab{\'o} and Veronika L{\'o}r{\'a}nd and {P{\'e}ter Sarl{\'o}s}, Don{\'a}t and T{\"u}nde Minier and Z. Proh{\'a}szka and L. Czirj{\'a}k and Cec{\'i}lia Varj{\'u}",
year = "2014",
doi = "10.1093/rheumatology/keu022",
language = "English",
volume = "53",
pages = "1439--1445",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis

AU - Farkas, Nelli

AU - Szabó, Andrea

AU - Lóránd, Veronika

AU - Péter Sarlós, Donát

AU - Minier, Tünde

AU - Prohászka, Z.

AU - Czirják, L.

AU - Varjú, Cecília

PY - 2014

Y1 - 2014

N2 - Objective. Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as a potential biomarker for the assessment of the severity of vascular involvement. Methods. One hundred and sixty-eight consecutive SSc patients-62 with dcSSc and 106 with lcSSc-were investigated at baseline and after 1-year of follow-up. Measurements in 93 patients with primary RP and 40 healthy subjects served as controls. Results. The median RDW value of patients with SSc was higher [14.2% (25th-75th percentiles 13.5-14.8%) compared with the group of primary RP patients [13.9% (13.4-14.4%); P5% during follow-up was associated with an average 8.9% decrease in left ventricular ejection fraction (LVEF) and 7% in DLCO and these associations were independent of each other. Conclusion. RDW in SSc may represent an integrative measure of multiple pathological processes including extensive vasculopathy, fibrosis or ongoing inflammation. An increase in RDW may indicate an impairment of cardiorespiratory function.

AB - Objective. Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as a potential biomarker for the assessment of the severity of vascular involvement. Methods. One hundred and sixty-eight consecutive SSc patients-62 with dcSSc and 106 with lcSSc-were investigated at baseline and after 1-year of follow-up. Measurements in 93 patients with primary RP and 40 healthy subjects served as controls. Results. The median RDW value of patients with SSc was higher [14.2% (25th-75th percentiles 13.5-14.8%) compared with the group of primary RP patients [13.9% (13.4-14.4%); P5% during follow-up was associated with an average 8.9% decrease in left ventricular ejection fraction (LVEF) and 7% in DLCO and these associations were independent of each other. Conclusion. RDW in SSc may represent an integrative measure of multiple pathological processes including extensive vasculopathy, fibrosis or ongoing inflammation. An increase in RDW may indicate an impairment of cardiorespiratory function.

KW - Inflammation

KW - Left ventricular ejection fraction

KW - Lung fibrosis

KW - RDW

KW - Red blood cell distribution width

KW - Systemic sclerosis

KW - Vasculopathy

UR - http://www.scopus.com/inward/record.url?scp=84904886141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904886141&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/keu022

DO - 10.1093/rheumatology/keu022

M3 - Article

C2 - 24659752

AN - SCOPUS:84904886141

VL - 53

SP - 1439

EP - 1445

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 8

M1 - keu022

ER -