A szervtranszplantációt követo non-melanoma bortumorok klinikai vizsgálata.

Translated title of the contribution: Clinical study of non-melanoma skin cancer following human organ transplantation

Tamás Fekecs, Zsolt Kádár, Zita Battyáni, Károly Kalmár-Nagy, Péter Szakály, G. Wéber, O. Horvath, A. Ferencz

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Increasing evidence suggests that non-melanoma skin cancers (NMSC) are the most frequent tumours in transplanted patients. In this study, we present the first Hungarian dermatological screening program to establish the incidence of NMSC after organ transplantations. PATIENTS AND METHODS: 116 adult, "Caucasian" (white skin) transplanted (kidney, simultaneous-pancreas-kidney) patients (70 male and 46 female) of the Surgical Department of Pécs University were enrolled from September 2008. All patients underwent a a full skin examination by a dermatologist for NMSC as well as a standardized questionnaire was filled in to assess risk factors. RESULTS: Screening resulted in 16 NMSC (13.8%, median age: 49.3 years, male : female = 1 : 1) diagnoses with a median duration from transplantation of 4.1 years. Histology showed 13 basal cell carcinoma (BBC), 3 squamous cell carcinoma (SCC), with a 4 : 1 ratio of BCC : SCC. Incidence of NMSC was significantly higher on patients who were treated with cyclosporine as immunosuppressant, who had more than 2 sunburns prior to transplantation, or had outdoor workplace ( p <0.05). CONCLUSIONS: These data confirm the importance of skin cancer surveillance in transplant recipients via a close cooperation between Transplantation and Dermatological Centres. Our results reflect the international data, except for the BCC : SCC ratio. Further studies needed to elucidate this difference.

Original languageHungarian
Pages (from-to)84-90
Number of pages7
JournalMagyar sebészet
Volume63
Issue number2
DOIs
Publication statusPublished - Apr 2010

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Organ Transplantation
Skin Neoplasms
Squamous Cell Carcinoma
Transplantation
Sunburn
Kidney
Skin
Basal Cell Carcinoma
Incidence
Immunosuppressive Agents
Workplace
Cyclosporine
Clinical Studies
Pancreas
Histology
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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A szervtranszplantációt követo non-melanoma bortumorok klinikai vizsgálata. / Fekecs, Tamás; Kádár, Zsolt; Battyáni, Zita; Kalmár-Nagy, Károly; Szakály, Péter; Wéber, G.; Horvath, O.; Ferencz, A.

In: Magyar sebészet, Vol. 63, No. 2, 04.2010, p. 84-90.

Research output: Contribution to journalArticle

Fekecs, Tamás ; Kádár, Zsolt ; Battyáni, Zita ; Kalmár-Nagy, Károly ; Szakály, Péter ; Wéber, G. ; Horvath, O. ; Ferencz, A. / A szervtranszplantációt követo non-melanoma bortumorok klinikai vizsgálata. In: Magyar sebészet. 2010 ; Vol. 63, No. 2. pp. 84-90.
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