Clinical significance of maternal anti-Ro/SS-A antibodies in children with isolated heart block

Ingrid M. Frohn-Mulder, Jan F. Meilof, A. Szatmári, Patricia A. Stewart, Tom J. Swaak, John Hess

Research output: Contribution to journalArticle

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Abstract

Objectives. We studied 30 consecutive children with isolated heart block to assess the clinical impact of the presence of maternal anti-Ro/SS-A antibodies for isolated heart block. Background. Isolated heart block in children, often associated with maternal autoimmune disease leading to anti-Ro/SS-A autoantibody production, is an infrequent but potentially lethal disorder. Methods. Thirty children with isolated heart block were studied with respect to medical history and electrocardiographic (ECG) analysis. The presence of anti-Ro/SS-A antibodies was determined in the maternal serum. We also examined the ECGs of all brothers and sisters of the patients for conduction abnormalities. Results. Twenty-one of the 30 children had an anti-Ro/SS-A-positive mother (group A); the other 9 children had an anti-Ro/ SS-A-negative mother (group B). Comparison of the clinical data from both mothers and children revealed that these two groups differed significantly with respect to the following: Prenatal diagnosis and obstetric complications occurred more often in group A, whereas progression to complete block, QRS width >0.08s, premature ventricular contractions and ventricular standstills >4.5 s occurred more often in group B. In addition, mothers of children in group A reported more spontaneous abortions. All siblings of children in groups A and B bad normal ECGs, excluding a subclinical form of heart block. Conclusions. Two types of heart block can be recognized: Congenital heart block is associated with maternal anti-Ro/SS-A antibodies and numerous obstetric and neonatal complications. It is diagnosed prenatally or at birth and is usually complete at onset and probably has a substantial recurrence risk. Heart block that is acquired later in life is not associated with maternal autoimmunity and has no risk for recurrence. It often presents as a partial block but progresses to complete block in time.

Original languageEnglish
Pages (from-to)1677-1681
Number of pages5
JournalJournal of the American College of Cardiology
Volume23
Issue number7
DOIs
Publication statusPublished - 1994

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Heart Block
Mothers
Siblings
Obstetrics
Electrocardiography
SS-A antibodies
Recurrence
Ventricular Premature Complexes
Spontaneous Abortion
Prenatal Diagnosis
Autoimmunity
Autoantibodies
Autoimmune Diseases
Parturition

ASJC Scopus subject areas

  • Nursing(all)

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Clinical significance of maternal anti-Ro/SS-A antibodies in children with isolated heart block. / Frohn-Mulder, Ingrid M.; Meilof, Jan F.; Szatmári, A.; Stewart, Patricia A.; Swaak, Tom J.; Hess, John.

In: Journal of the American College of Cardiology, Vol. 23, No. 7, 1994, p. 1677-1681.

Research output: Contribution to journalArticle

Frohn-Mulder, Ingrid M. ; Meilof, Jan F. ; Szatmári, A. ; Stewart, Patricia A. ; Swaak, Tom J. ; Hess, John. / Clinical significance of maternal anti-Ro/SS-A antibodies in children with isolated heart block. In: Journal of the American College of Cardiology. 1994 ; Vol. 23, No. 7. pp. 1677-1681.
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abstract = "Objectives. We studied 30 consecutive children with isolated heart block to assess the clinical impact of the presence of maternal anti-Ro/SS-A antibodies for isolated heart block. Background. Isolated heart block in children, often associated with maternal autoimmune disease leading to anti-Ro/SS-A autoantibody production, is an infrequent but potentially lethal disorder. Methods. Thirty children with isolated heart block were studied with respect to medical history and electrocardiographic (ECG) analysis. The presence of anti-Ro/SS-A antibodies was determined in the maternal serum. We also examined the ECGs of all brothers and sisters of the patients for conduction abnormalities. Results. Twenty-one of the 30 children had an anti-Ro/SS-A-positive mother (group A); the other 9 children had an anti-Ro/ SS-A-negative mother (group B). Comparison of the clinical data from both mothers and children revealed that these two groups differed significantly with respect to the following: Prenatal diagnosis and obstetric complications occurred more often in group A, whereas progression to complete block, QRS width >0.08s, premature ventricular contractions and ventricular standstills >4.5 s occurred more often in group B. In addition, mothers of children in group A reported more spontaneous abortions. All siblings of children in groups A and B bad normal ECGs, excluding a subclinical form of heart block. Conclusions. Two types of heart block can be recognized: Congenital heart block is associated with maternal anti-Ro/SS-A antibodies and numerous obstetric and neonatal complications. It is diagnosed prenatally or at birth and is usually complete at onset and probably has a substantial recurrence risk. Heart block that is acquired later in life is not associated with maternal autoimmunity and has no risk for recurrence. It often presents as a partial block but progresses to complete block in time.",
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AU - Stewart, Patricia A.

AU - Swaak, Tom J.

AU - Hess, John

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N2 - Objectives. We studied 30 consecutive children with isolated heart block to assess the clinical impact of the presence of maternal anti-Ro/SS-A antibodies for isolated heart block. Background. Isolated heart block in children, often associated with maternal autoimmune disease leading to anti-Ro/SS-A autoantibody production, is an infrequent but potentially lethal disorder. Methods. Thirty children with isolated heart block were studied with respect to medical history and electrocardiographic (ECG) analysis. The presence of anti-Ro/SS-A antibodies was determined in the maternal serum. We also examined the ECGs of all brothers and sisters of the patients for conduction abnormalities. Results. Twenty-one of the 30 children had an anti-Ro/SS-A-positive mother (group A); the other 9 children had an anti-Ro/ SS-A-negative mother (group B). Comparison of the clinical data from both mothers and children revealed that these two groups differed significantly with respect to the following: Prenatal diagnosis and obstetric complications occurred more often in group A, whereas progression to complete block, QRS width >0.08s, premature ventricular contractions and ventricular standstills >4.5 s occurred more often in group B. In addition, mothers of children in group A reported more spontaneous abortions. All siblings of children in groups A and B bad normal ECGs, excluding a subclinical form of heart block. Conclusions. Two types of heart block can be recognized: Congenital heart block is associated with maternal anti-Ro/SS-A antibodies and numerous obstetric and neonatal complications. It is diagnosed prenatally or at birth and is usually complete at onset and probably has a substantial recurrence risk. Heart block that is acquired later in life is not associated with maternal autoimmunity and has no risk for recurrence. It often presents as a partial block but progresses to complete block in time.

AB - Objectives. We studied 30 consecutive children with isolated heart block to assess the clinical impact of the presence of maternal anti-Ro/SS-A antibodies for isolated heart block. Background. Isolated heart block in children, often associated with maternal autoimmune disease leading to anti-Ro/SS-A autoantibody production, is an infrequent but potentially lethal disorder. Methods. Thirty children with isolated heart block were studied with respect to medical history and electrocardiographic (ECG) analysis. The presence of anti-Ro/SS-A antibodies was determined in the maternal serum. We also examined the ECGs of all brothers and sisters of the patients for conduction abnormalities. Results. Twenty-one of the 30 children had an anti-Ro/SS-A-positive mother (group A); the other 9 children had an anti-Ro/ SS-A-negative mother (group B). Comparison of the clinical data from both mothers and children revealed that these two groups differed significantly with respect to the following: Prenatal diagnosis and obstetric complications occurred more often in group A, whereas progression to complete block, QRS width >0.08s, premature ventricular contractions and ventricular standstills >4.5 s occurred more often in group B. In addition, mothers of children in group A reported more spontaneous abortions. All siblings of children in groups A and B bad normal ECGs, excluding a subclinical form of heart block. Conclusions. Two types of heart block can be recognized: Congenital heart block is associated with maternal anti-Ro/SS-A antibodies and numerous obstetric and neonatal complications. It is diagnosed prenatally or at birth and is usually complete at onset and probably has a substantial recurrence risk. Heart block that is acquired later in life is not associated with maternal autoimmunity and has no risk for recurrence. It often presents as a partial block but progresses to complete block in time.

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