Az emlótumor csontveló mikrometasztázisának klinikai jelentósége.

Translated title of the contribution: Clinical significance of bone marrow micrometastases of breast tumors

Sándor Dubecz, Orsolya Csuka, Klára Török, Norbert Vasas, Gábor Péley, Zoltán Doleschal, Zoltán Sulyok, István Láng, István Köves

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Detection of hematogenous micrometastases (MM) in bone marrow might play important role in determining stage, prognosis and multimodality treatment strategy of invasive breast cancer. Therefore we studied the presence of occult tumor cells in bone marrow of outpatients operated on with breast cancer by detecting cytokeratin 20 mRNA using the RT-PCR method. In 182 primary breast cancer patients 54 (29.7%) micrometastases were detected while in 128 patients (70.3%) no tumor cells were found in the bone marrow aspirates. Correlation of MM with HER-2, c-met, nm23, p53 and estrogen receptor (ER) were studied. The presence of MM was correlated with HER-2, nm23- and p53 positivity and with low frequency of nm23 and ER. The possible role of bone marrow MM in selecting node negative breast cancer patients for adjuvant therapy should be tested in randomized prospective clinical trials.

Original languageHungarian
Pages (from-to)108-112
Number of pages5
JournalMagyar sebészet
Issue number3-4
Publication statusPublished - Aug 2003


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dubecz, S., Csuka, O., Török, K., Vasas, N., Péley, G., Doleschal, Z., Sulyok, Z., Láng, I., & Köves, I. (2003). Az emlótumor csontveló mikrometasztázisának klinikai jelentósége. Magyar sebészet, 56(3-4), 108-112.