Elõrehaladott méhnyakdaganatok képvezérelt adaptív kombinált intrakavitális-intersticiális brahiterápiájának bevezetése Magyarországon

Translated title of the contribution: Clinical results of combined intracavitary-interstitial image-guided adaptive brachytherapy in locally advanced cervical cancer

Júlia Vízkeleti, Georgina Fröhlich, Nguyen Anhhong Nhung, Katalin Horváth, T. Major, C. Polgár

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We present the early clinical results achieved with image-guided adaptive brachytherapy (IGABT) with combined intracavitary-interstitial (IC-IS) technique recently implemented in Hungary in the treatment of locally advanced cervical cancer (LACC). Twenty-one patients were treated with radio-chemotherapy (RCT) followed by combined IC-IS BT. At the end of the RCT we assessed the residual tumour with pelvic MRI. On CT images registered with the applicator in place we contoured the organs at risk and the high-risk clinical target volume, which included the whole cervix and the eventual residual tumour in the parametria. No grade 4 toxicity was noticed. At 11 months follow-up the local control rate was 92.3%, the pelvic control rate 86.5%, the distant metastasis free survival and the disease-free survival were 74%. The combined IC-IS treatment was well tolerated. Our clinical results are similar to those reported in the literature.

Original languageHungarian
Pages (from-to)249-257
Number of pages9
JournalMagyar Onkologia
Volume62
Issue number4
Publication statusPublished - Dec 12 2018

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Brachytherapy
Residual Neoplasm
Radio
Uterine Cervical Neoplasms
Organs at Risk
Drug Therapy
Hungary
Peritoneum
Cervix Uteri
Disease-Free Survival
Neoplasm Metastasis
Therapeutics

ASJC Scopus subject areas

  • Oncology

Cite this

Elõrehaladott méhnyakdaganatok képvezérelt adaptív kombinált intrakavitális-intersticiális brahiterápiájának bevezetése Magyarországon. / Vízkeleti, Júlia; Fröhlich, Georgina; Nhung, Nguyen Anhhong; Horváth, Katalin; Major, T.; Polgár, C.

In: Magyar Onkologia, Vol. 62, No. 4, 12.12.2018, p. 249-257.

Research output: Contribution to journalArticle

Vízkeleti, Júlia ; Fröhlich, Georgina ; Nhung, Nguyen Anhhong ; Horváth, Katalin ; Major, T. ; Polgár, C. / Elõrehaladott méhnyakdaganatok képvezérelt adaptív kombinált intrakavitális-intersticiális brahiterápiájának bevezetése Magyarországon. In: Magyar Onkologia. 2018 ; Vol. 62, No. 4. pp. 249-257.
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abstract = "We present the early clinical results achieved with image-guided adaptive brachytherapy (IGABT) with combined intracavitary-interstitial (IC-IS) technique recently implemented in Hungary in the treatment of locally advanced cervical cancer (LACC). Twenty-one patients were treated with radio-chemotherapy (RCT) followed by combined IC-IS BT. At the end of the RCT we assessed the residual tumour with pelvic MRI. On CT images registered with the applicator in place we contoured the organs at risk and the high-risk clinical target volume, which included the whole cervix and the eventual residual tumour in the parametria. No grade 4 toxicity was noticed. At 11 months follow-up the local control rate was 92.3{\%}, the pelvic control rate 86.5{\%}, the distant metastasis free survival and the disease-free survival were 74{\%}. The combined IC-IS treatment was well tolerated. Our clinical results are similar to those reported in the literature.",
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