KLINISCHE WERTIGKEIT DER MESSUNG DES ATRIALEN NATRIURETISCHEN PEPTIDS IM PLASMA VON KINDERN MIT CHRONISCHER NIERENINSUFFIZIENZ

Translated title of the contribution: Clinical relevance of determination of plasma atrial natriuretic peptide in children with chronic renal failure

W. Rascher, M. Bald, F. Kroner, T. Tulassay, D. E. Muller-Wiefel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To investigate whether plasma atrial natriuretic peptide (ANP) is a valuable index to detect fluid expansion in children with endstage renal disease, we studied 34 children and adolescents on regular intermittent hemodialysis or on continuous ambulatory peritoneal dialysis (CAPD). In 22 pediatric patients, plasma ANP was markedly elevated prior to hemodialysis and fell to near normal levels after dialysis (109.9 ± 80.0 to 39.0 ± 23.1 fmol/ml x̄ ± SD). During removal of fluid excess by 1-h sequential ultrafiltration without dialysis in eight adolescents, plasma ANP fell from 123.8 ± 97.0 to 45.3 ± 24.6 fmol/ml. Ultrafiltration was followed by 3 h hemodialysis with fluid removal and ANP decreased further to 29.6 ± 12.1 fmol/ml. In 12 patients on CAPD, plasma ANP was similar to that in 96 healthy control children (29.3 ± 28.9 vs 23.9 ± 11.9 fmol/ml) and did not differ from that in 12 children with advanced chronic renal failure (32.6 ± 20.1 fmol/ml) and seven successfully transplanted children (32.4 ± 8.5 fmol/ml). Four patients on hemodialysis (post dialysis), one on CAPD and two with advanced chronic renal failure had definitely elevated ANP levels (>56 fmol/ml = >3 SD mean of controls) indicating fluid volume overload. It is concluded that plasma ANP is elevated in children with chronic renal failure due to volume expansion and that measurement of plasma ANP is a sensitive marker to detect fluid overload in these children.

Translated title of the contributionClinical relevance of determination of plasma atrial natriuretic peptide in children with chronic renal failure
Original languageGerman
Pages (from-to)61-64
Number of pages4
JournalZeitschrift fur Kardiologie
Volume77
Issue numberSUPPL. 2
Publication statusPublished - Jan 1 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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