Clinical, radiological and pathological correlates of leukoaraiosis

E. Auriel, N. M. Bornstein, E. Berenyi, I. Varkonyi, M. Gabor, K. Majtenyi, R. Szepesi, I. Goldberg, R. Lampe, L. Csiba

Research output: Contribution to journalArticle

29 Citations (Scopus)


Introduction Leukoaraiosis is characterized by an abnormal appearance of the brain white matter on imaging. Its pathogenesis is still a matter of investigation. The purpose of this study was to investigate the radiological, clinical and pathological correlates of leukoaraiosis. Methods The study population consisted of 93 deceased patients. The pre-mortem T2W magnetic resonance images were evaluated for the presence and grading of leukoaraiosis. The clinical and pathological characteristics based on the clinical charts and autopsy reports were evaluated. Tissue specimens of the blocks of 19 brains that demonstrated severe leukoaraiosis and those of five control brains were excised and stained. Results The variables found to be significantly associated with leukoaraiosis were age and a clinical history of Parkinson's disease. Other risk factors and pathological markers of atherosclerosis were not significantly correlated with leukoaraiosis. No significant difference was found between the scoring of the myelin integrity, glial fibrillary acidic protein, cluster of differentiation 68 and smooth muscle actin. There was a significant difference with respect to thickening of vessels walls. Conclusions Our pathological results indicate that structural vascular abnormalities characterized by vessel wall thickening are associated with leukoaraiosis, supporting the assertion that vascular changes and ischemia generate leukoaraiosis. The relations between parkinsonism and leukoaraiosis may be explicable through vascular effects on the circuitry of the basal ganglia.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalActa Neurologica Scandinavica
Issue number1
Publication statusPublished - Jan 1 2011



  • Brain MRI
  • Leukoaraiosis
  • Small vessels disease
  • White matter

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this