Clinical presentation at first heart failure hospitalization does not predict recurrent heart failure admission

Annamaria Kosztin, Jason Costa, Arthur J. Moss, Yitschak Biton, Vivien Klaudia Nagy, Scott D. Solomon, L. Gellér, Scott McNitt, Bronislava Polonsky, B. Merkely, Valentina Kutyifa

Research output: Contribution to journalArticle

Abstract

METHODS AND RESULTS: Data on HF hospitalizations were prospectively collected for patients enrolled in MADIT-CRT. Predictors of recurrent HF hospitalization (HF2) after the first HF hospitalization were assessed using Cox proportional hazards regression models including baseline covariates and clinical presentation or management at first HF hospitalization. There were 193 patients with first HF hospitalization, and 156 patients with recurrent HF events. Recurrent HF rate after the first HF hospitalization was 43% at 1 year, 52% at 2 years, and 55% at 2.5 years. Clinical signs and symptoms, medical treatment, or clinical management of HF at first HF admission was not predictive for HF2. Baseline covariates predicting recurrent HF hospitalization included prior HF hospitalization (HR = 1.59, 95% CI: 1.15-2.20, P = 0.005), digitalis therapy (HR = 1.58, 95% CI: 1.13-2.20, P = 0.008), and left ventricular end-diastolic volume >240 mL (HR = 1.62, 95% CI: 1.17-2.25, P = 0.004).

CONCLUSIONS: Recurrent HF events are frequent following the first HF hospitalization in patients with implanted implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator. Neither clinical presentation nor clinical management during first HF admission was predictive of recurrent HF. Prior HF hospitalization, digitalis therapy, and left ventricular end-diastolic volume at enrolment predicted recurrent HF hospitalization, and these covariates could be used as surrogate markers for identifying a high-risk cohort.

AIMS: There are limited data on whether clinical presentation at first heart failure (HF) hospitalization predicts recurrent HF events. We aimed to assess predictors of recurrent HF hospitalizations in mild HF patients with an implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator.

Original languageEnglish
Pages (from-to)520-526
Number of pages7
JournalESC heart failure
Volume4
Issue number4
DOIs
Publication statusPublished - Nov 1 2017

Fingerprint

Hospitalization
Heart Failure
Cardiac Resynchronization Therapy
Defibrillators
Digitalis
Implantable Defibrillators
Stroke Volume
Proportional Hazards Models
Signs and Symptoms

Keywords

  • Cardiac resynchronization therapy
  • Heart failure hospitalization
  • Recurrent hospitalization

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kosztin, A., Costa, J., Moss, A. J., Biton, Y., Nagy, V. K., Solomon, S. D., ... Kutyifa, V. (2017). Clinical presentation at first heart failure hospitalization does not predict recurrent heart failure admission. ESC heart failure, 4(4), 520-526. https://doi.org/10.1002/ehf2.12157

Clinical presentation at first heart failure hospitalization does not predict recurrent heart failure admission. / Kosztin, Annamaria; Costa, Jason; Moss, Arthur J.; Biton, Yitschak; Nagy, Vivien Klaudia; Solomon, Scott D.; Gellér, L.; McNitt, Scott; Polonsky, Bronislava; Merkely, B.; Kutyifa, Valentina.

In: ESC heart failure, Vol. 4, No. 4, 01.11.2017, p. 520-526.

Research output: Contribution to journalArticle

Kosztin, A, Costa, J, Moss, AJ, Biton, Y, Nagy, VK, Solomon, SD, Gellér, L, McNitt, S, Polonsky, B, Merkely, B & Kutyifa, V 2017, 'Clinical presentation at first heart failure hospitalization does not predict recurrent heart failure admission', ESC heart failure, vol. 4, no. 4, pp. 520-526. https://doi.org/10.1002/ehf2.12157
Kosztin, Annamaria ; Costa, Jason ; Moss, Arthur J. ; Biton, Yitschak ; Nagy, Vivien Klaudia ; Solomon, Scott D. ; Gellér, L. ; McNitt, Scott ; Polonsky, Bronislava ; Merkely, B. ; Kutyifa, Valentina. / Clinical presentation at first heart failure hospitalization does not predict recurrent heart failure admission. In: ESC heart failure. 2017 ; Vol. 4, No. 4. pp. 520-526.
@article{b76ac37c93414b46a6e2ce51566c7a22,
title = "Clinical presentation at first heart failure hospitalization does not predict recurrent heart failure admission",
abstract = "METHODS AND RESULTS: Data on HF hospitalizations were prospectively collected for patients enrolled in MADIT-CRT. Predictors of recurrent HF hospitalization (HF2) after the first HF hospitalization were assessed using Cox proportional hazards regression models including baseline covariates and clinical presentation or management at first HF hospitalization. There were 193 patients with first HF hospitalization, and 156 patients with recurrent HF events. Recurrent HF rate after the first HF hospitalization was 43{\%} at 1 year, 52{\%} at 2 years, and 55{\%} at 2.5 years. Clinical signs and symptoms, medical treatment, or clinical management of HF at first HF admission was not predictive for HF2. Baseline covariates predicting recurrent HF hospitalization included prior HF hospitalization (HR = 1.59, 95{\%} CI: 1.15-2.20, P = 0.005), digitalis therapy (HR = 1.58, 95{\%} CI: 1.13-2.20, P = 0.008), and left ventricular end-diastolic volume >240 mL (HR = 1.62, 95{\%} CI: 1.17-2.25, P = 0.004).CONCLUSIONS: Recurrent HF events are frequent following the first HF hospitalization in patients with implanted implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator. Neither clinical presentation nor clinical management during first HF admission was predictive of recurrent HF. Prior HF hospitalization, digitalis therapy, and left ventricular end-diastolic volume at enrolment predicted recurrent HF hospitalization, and these covariates could be used as surrogate markers for identifying a high-risk cohort.AIMS: There are limited data on whether clinical presentation at first heart failure (HF) hospitalization predicts recurrent HF events. We aimed to assess predictors of recurrent HF hospitalizations in mild HF patients with an implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator.",
keywords = "Cardiac resynchronization therapy, Heart failure hospitalization, Recurrent hospitalization",
author = "Annamaria Kosztin and Jason Costa and Moss, {Arthur J.} and Yitschak Biton and Nagy, {Vivien Klaudia} and Solomon, {Scott D.} and L. Gell{\'e}r and Scott McNitt and Bronislava Polonsky and B. Merkely and Valentina Kutyifa",
year = "2017",
month = "11",
day = "1",
doi = "10.1002/ehf2.12157",
language = "English",
volume = "4",
pages = "520--526",
journal = "ESC heart failure",
issn = "2055-5822",
publisher = "The Heart Failure Association of the European Society of Cardiology",
number = "4",

}

TY - JOUR

T1 - Clinical presentation at first heart failure hospitalization does not predict recurrent heart failure admission

AU - Kosztin, Annamaria

AU - Costa, Jason

AU - Moss, Arthur J.

AU - Biton, Yitschak

AU - Nagy, Vivien Klaudia

AU - Solomon, Scott D.

AU - Gellér, L.

AU - McNitt, Scott

AU - Polonsky, Bronislava

AU - Merkely, B.

AU - Kutyifa, Valentina

PY - 2017/11/1

Y1 - 2017/11/1

N2 - METHODS AND RESULTS: Data on HF hospitalizations were prospectively collected for patients enrolled in MADIT-CRT. Predictors of recurrent HF hospitalization (HF2) after the first HF hospitalization were assessed using Cox proportional hazards regression models including baseline covariates and clinical presentation or management at first HF hospitalization. There were 193 patients with first HF hospitalization, and 156 patients with recurrent HF events. Recurrent HF rate after the first HF hospitalization was 43% at 1 year, 52% at 2 years, and 55% at 2.5 years. Clinical signs and symptoms, medical treatment, or clinical management of HF at first HF admission was not predictive for HF2. Baseline covariates predicting recurrent HF hospitalization included prior HF hospitalization (HR = 1.59, 95% CI: 1.15-2.20, P = 0.005), digitalis therapy (HR = 1.58, 95% CI: 1.13-2.20, P = 0.008), and left ventricular end-diastolic volume >240 mL (HR = 1.62, 95% CI: 1.17-2.25, P = 0.004).CONCLUSIONS: Recurrent HF events are frequent following the first HF hospitalization in patients with implanted implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator. Neither clinical presentation nor clinical management during first HF admission was predictive of recurrent HF. Prior HF hospitalization, digitalis therapy, and left ventricular end-diastolic volume at enrolment predicted recurrent HF hospitalization, and these covariates could be used as surrogate markers for identifying a high-risk cohort.AIMS: There are limited data on whether clinical presentation at first heart failure (HF) hospitalization predicts recurrent HF events. We aimed to assess predictors of recurrent HF hospitalizations in mild HF patients with an implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator.

AB - METHODS AND RESULTS: Data on HF hospitalizations were prospectively collected for patients enrolled in MADIT-CRT. Predictors of recurrent HF hospitalization (HF2) after the first HF hospitalization were assessed using Cox proportional hazards regression models including baseline covariates and clinical presentation or management at first HF hospitalization. There were 193 patients with first HF hospitalization, and 156 patients with recurrent HF events. Recurrent HF rate after the first HF hospitalization was 43% at 1 year, 52% at 2 years, and 55% at 2.5 years. Clinical signs and symptoms, medical treatment, or clinical management of HF at first HF admission was not predictive for HF2. Baseline covariates predicting recurrent HF hospitalization included prior HF hospitalization (HR = 1.59, 95% CI: 1.15-2.20, P = 0.005), digitalis therapy (HR = 1.58, 95% CI: 1.13-2.20, P = 0.008), and left ventricular end-diastolic volume >240 mL (HR = 1.62, 95% CI: 1.17-2.25, P = 0.004).CONCLUSIONS: Recurrent HF events are frequent following the first HF hospitalization in patients with implanted implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator. Neither clinical presentation nor clinical management during first HF admission was predictive of recurrent HF. Prior HF hospitalization, digitalis therapy, and left ventricular end-diastolic volume at enrolment predicted recurrent HF hospitalization, and these covariates could be used as surrogate markers for identifying a high-risk cohort.AIMS: There are limited data on whether clinical presentation at first heart failure (HF) hospitalization predicts recurrent HF events. We aimed to assess predictors of recurrent HF hospitalizations in mild HF patients with an implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator.

KW - Cardiac resynchronization therapy

KW - Heart failure hospitalization

KW - Recurrent hospitalization

UR - http://www.scopus.com/inward/record.url?scp=85049890861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049890861&partnerID=8YFLogxK

U2 - 10.1002/ehf2.12157

DO - 10.1002/ehf2.12157

M3 - Article

C2 - 28960867

AN - SCOPUS:85049890861

VL - 4

SP - 520

EP - 526

JO - ESC heart failure

JF - ESC heart failure

SN - 2055-5822

IS - 4

ER -