Clinical-pharmacological Testing for Parasympatholytic Drugs

G. Mózsik, T. Jávor

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

1. Two methods were established being sufficient in clinical pharmacological investigation of parasympatholytic drugs: the collection of isolated parotid saliva and the bioassay of the drug excreted with the urine. 2. After administration of these drugs the basal and reflectoric secretion of the parotid saliva diminishes. 3. The bioassay of the drug excreted with the urine is suitable for evaluating the difference in absorption between the doses applied orally and parenterally. It reflects fairly well the actual blood level too. 4. The effect of a single dose of atropin lasts for 3-4 hours, the same of Isopropamide (Priamide) for 10-15 hours. The parenteral-oral dose rate of atropin is 1 :1, that of Isopropamide (Priamide) is 4-6 : 1.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalPharmacology
Volume14
Issue number2
DOIs
Publication statusPublished - 1966

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Parasympatholytics
Pharmacology
Saliva
Biological Assay
Urine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Clinical-pharmacological Testing for Parasympatholytic Drugs. / Mózsik, G.; Jávor, T.

In: Pharmacology, Vol. 14, No. 2, 1966, p. 183-190.

Research output: Contribution to journalArticle

Mózsik, G. ; Jávor, T. / Clinical-pharmacological Testing for Parasympatholytic Drugs. In: Pharmacology. 1966 ; Vol. 14, No. 2. pp. 183-190.
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