Observaţii clinice privind antagonizarea cu sugammadex a blocului neuromuscular cu rocuronium în chirurgia toracicǎ

Translated title of the contribution: Clinical observations on reversal of rocuronium-induced residual neuromuscular blockade by sugammadex after thoracic surgery

Tamás Végh, Marianna Juhász, István László, Attila Vaskó, E. Tassonyi, B. Fülesdi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: After thoracic surgery, a complete reversal of neuromuscular blockade (NMB) facilitates ventilatory movements and expectoration and enhances the possibility of early physiotherapy. Therefore, the aim of the present study was to evaluate the clinical usefulness of sugammadex for reversal of NMB after anaesthesia for thoracic surgery. Design: Prospective case series. Setting: University hospital. Participants: 49 patients undergoing thoracic surgical procedures (25 thoracotomies, 11 video-assisted thoracoscopies and 13 mediastinosciopies) were included. Interventions: Rocuronium was used for intubation and maintenance of NMB under continuous monitoring with TOF Watch SX acceleromyograph. Residual NMB at the end of surgery was reversed by administration of sugammadex 2 mg/kg BW. Main results: All patients had a residual curarisation at the end of surgery (TOF: 27.02 ± 25.9%). Time to 100% TOF recovery after sugammadex averaged 2.46 ± 0.58 minutes. Thirty three out of 49 patients had mild hypothermia at the end of surgery. There was no difference in time needed for TOF recovery to 100% between hypothermic and normothermic patients (hypothermic: 2.46 ± 2.9 minutes, normothermic: 1.81 ± 0.76 minutes, p = 0.29). Postoperative shivering occurred in 67% of the patients. Conclusions: We conclude that sugammadex allows fast and complete recovery of the neuromuscular function after thoracic surgical procedures even if mild hypothermia was present.

Original languageUndefined/Unknown
Pages (from-to)7-11
Number of pages5
JournalJurnalul Roman de Anestezie Terapie Intensiva/Romanian Journal of Anaesthesia and Intensive Care
Volume21
Issue number1
Publication statusPublished - 2014

Fingerprint

Delayed Emergence from Anesthesia
Thoracic Surgery
Neuromuscular Blockade
Thoracic Surgical Procedures
Hypothermia
Shivering
Thoracoscopy
Recovery of Function
Thoracotomy
Intubation
Anesthesia
Maintenance
Sugammadex
rocuronium

Keywords

  • Residual curarisation
  • Rocuronium
  • Sugammadex
  • Thoracic anaesthesia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

@article{6410e5751fb546388a620304eedc9e84,
title = "Observaţii clinice privind antagonizarea cu sugammadex a blocului neuromuscular cu rocuronium {\^i}n chirurgia toracicǎ",
abstract = "Objective: After thoracic surgery, a complete reversal of neuromuscular blockade (NMB) facilitates ventilatory movements and expectoration and enhances the possibility of early physiotherapy. Therefore, the aim of the present study was to evaluate the clinical usefulness of sugammadex for reversal of NMB after anaesthesia for thoracic surgery. Design: Prospective case series. Setting: University hospital. Participants: 49 patients undergoing thoracic surgical procedures (25 thoracotomies, 11 video-assisted thoracoscopies and 13 mediastinosciopies) were included. Interventions: Rocuronium was used for intubation and maintenance of NMB under continuous monitoring with TOF Watch SX acceleromyograph. Residual NMB at the end of surgery was reversed by administration of sugammadex 2 mg/kg BW. Main results: All patients had a residual curarisation at the end of surgery (TOF: 27.02 ± 25.9{\%}). Time to 100{\%} TOF recovery after sugammadex averaged 2.46 ± 0.58 minutes. Thirty three out of 49 patients had mild hypothermia at the end of surgery. There was no difference in time needed for TOF recovery to 100{\%} between hypothermic and normothermic patients (hypothermic: 2.46 ± 2.9 minutes, normothermic: 1.81 ± 0.76 minutes, p = 0.29). Postoperative shivering occurred in 67{\%} of the patients. Conclusions: We conclude that sugammadex allows fast and complete recovery of the neuromuscular function after thoracic surgical procedures even if mild hypothermia was present.",
keywords = "Residual curarisation, Rocuronium, Sugammadex, Thoracic anaesthesia",
author = "Tam{\'a}s V{\'e}gh and Marianna Juh{\'a}sz and Istv{\'a}n L{\'a}szl{\'o} and Attila Vask{\'o} and E. Tassonyi and B. F{\"u}lesdi",
year = "2014",
language = "Undefined/Unknown",
volume = "21",
pages = "7--11",
journal = "Romanian Journal of Anaesthesia and Intensive Care",
issn = "2392-7518",
publisher = "Atlas- Clusium",
number = "1",

}

TY - JOUR

T1 - Observaţii clinice privind antagonizarea cu sugammadex a blocului neuromuscular cu rocuronium în chirurgia toracicǎ

AU - Végh, Tamás

AU - Juhász, Marianna

AU - László, István

AU - Vaskó, Attila

AU - Tassonyi, E.

AU - Fülesdi, B.

PY - 2014

Y1 - 2014

N2 - Objective: After thoracic surgery, a complete reversal of neuromuscular blockade (NMB) facilitates ventilatory movements and expectoration and enhances the possibility of early physiotherapy. Therefore, the aim of the present study was to evaluate the clinical usefulness of sugammadex for reversal of NMB after anaesthesia for thoracic surgery. Design: Prospective case series. Setting: University hospital. Participants: 49 patients undergoing thoracic surgical procedures (25 thoracotomies, 11 video-assisted thoracoscopies and 13 mediastinosciopies) were included. Interventions: Rocuronium was used for intubation and maintenance of NMB under continuous monitoring with TOF Watch SX acceleromyograph. Residual NMB at the end of surgery was reversed by administration of sugammadex 2 mg/kg BW. Main results: All patients had a residual curarisation at the end of surgery (TOF: 27.02 ± 25.9%). Time to 100% TOF recovery after sugammadex averaged 2.46 ± 0.58 minutes. Thirty three out of 49 patients had mild hypothermia at the end of surgery. There was no difference in time needed for TOF recovery to 100% between hypothermic and normothermic patients (hypothermic: 2.46 ± 2.9 minutes, normothermic: 1.81 ± 0.76 minutes, p = 0.29). Postoperative shivering occurred in 67% of the patients. Conclusions: We conclude that sugammadex allows fast and complete recovery of the neuromuscular function after thoracic surgical procedures even if mild hypothermia was present.

AB - Objective: After thoracic surgery, a complete reversal of neuromuscular blockade (NMB) facilitates ventilatory movements and expectoration and enhances the possibility of early physiotherapy. Therefore, the aim of the present study was to evaluate the clinical usefulness of sugammadex for reversal of NMB after anaesthesia for thoracic surgery. Design: Prospective case series. Setting: University hospital. Participants: 49 patients undergoing thoracic surgical procedures (25 thoracotomies, 11 video-assisted thoracoscopies and 13 mediastinosciopies) were included. Interventions: Rocuronium was used for intubation and maintenance of NMB under continuous monitoring with TOF Watch SX acceleromyograph. Residual NMB at the end of surgery was reversed by administration of sugammadex 2 mg/kg BW. Main results: All patients had a residual curarisation at the end of surgery (TOF: 27.02 ± 25.9%). Time to 100% TOF recovery after sugammadex averaged 2.46 ± 0.58 minutes. Thirty three out of 49 patients had mild hypothermia at the end of surgery. There was no difference in time needed for TOF recovery to 100% between hypothermic and normothermic patients (hypothermic: 2.46 ± 2.9 minutes, normothermic: 1.81 ± 0.76 minutes, p = 0.29). Postoperative shivering occurred in 67% of the patients. Conclusions: We conclude that sugammadex allows fast and complete recovery of the neuromuscular function after thoracic surgical procedures even if mild hypothermia was present.

KW - Residual curarisation

KW - Rocuronium

KW - Sugammadex

KW - Thoracic anaesthesia

UR - http://www.scopus.com/inward/record.url?scp=84901398869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901398869&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84901398869

VL - 21

SP - 7

EP - 11

JO - Romanian Journal of Anaesthesia and Intensive Care

JF - Romanian Journal of Anaesthesia and Intensive Care

SN - 2392-7518

IS - 1

ER -