Klinikai tapasztalataink cutan mastocytosisban

Translated title of the contribution: Clinical observations in cutan mastocytosis

Noémi Mihalik, Bernadett Hidvégi, Judit Hársing, J. Várkonyi, Judit Csomor, I. Kovalszky, Márta Marschalkó, S. Kárpáti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Mastocytosis is a clonal mast cell proliferative disease, devided into cutaneous and systemic forms. The characteristic symptoms are caused by neoplastic mast cell infiltrations in different organs and/or the release of mediators. Aim: The aim of the authors was to summarize their clinical observations in patients with mastocytosis. Method: 22 adult patients diagnosed consecutively with mastocytosis were enrolled in the study. Skin and bone marrow biopsies were taken to establish the diagnosis and perform c-KIT mutation (D816V) analysis. Results: One of the 22 patients had teleangiectasia macularis eruptiva perstans, while 20/22 patients had urticaria pigmentosa. All patients had cutaneous lesions. In 12 patients iliac crest biopsy was performed and 9 of them had bone marrow involvement, classified as indolent systemic mastocytosis. The c-kit mutation D816V was found in one subject both in skin and bone marrow samples. The patients were treated with antihistamine, PUVA, interferon-α or imatinib. Conclusions: The authors draw attention to this rare disease in order to help recognition of relevant signs and symptoms and establish an early diagnosis.

Original languageHungarian
Pages (from-to)1469-1475
Number of pages7
JournalOrvosi Hetilap
Volume154
Issue number37
DOIs
Publication statusPublished - Sep 1 2013

Fingerprint

Mastocytosis
Skin
Bone Marrow
Urticaria Pigmentosa
Systemic Mastocytosis
Biopsy
Mutation
Histamine Antagonists
Rare Diseases
Mast Cells
Interferons
Signs and Symptoms
Early Diagnosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Klinikai tapasztalataink cutan mastocytosisban. / Mihalik, Noémi; Hidvégi, Bernadett; Hársing, Judit; Várkonyi, J.; Csomor, Judit; Kovalszky, I.; Marschalkó, Márta; Kárpáti, S.

In: Orvosi Hetilap, Vol. 154, No. 37, 01.09.2013, p. 1469-1475.

Research output: Contribution to journalArticle

Mihalik, N, Hidvégi, B, Hársing, J, Várkonyi, J, Csomor, J, Kovalszky, I, Marschalkó, M & Kárpáti, S 2013, 'Klinikai tapasztalataink cutan mastocytosisban', Orvosi Hetilap, vol. 154, no. 37, pp. 1469-1475. https://doi.org/10.1556/OH.2013.29702
Mihalik N, Hidvégi B, Hársing J, Várkonyi J, Csomor J, Kovalszky I et al. Klinikai tapasztalataink cutan mastocytosisban. Orvosi Hetilap. 2013 Sep 1;154(37):1469-1475. https://doi.org/10.1556/OH.2013.29702
Mihalik, Noémi ; Hidvégi, Bernadett ; Hársing, Judit ; Várkonyi, J. ; Csomor, Judit ; Kovalszky, I. ; Marschalkó, Márta ; Kárpáti, S. / Klinikai tapasztalataink cutan mastocytosisban. In: Orvosi Hetilap. 2013 ; Vol. 154, No. 37. pp. 1469-1475.
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