Clinical Manifestations of Genetic Instability Overlap One Another

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cancer syndromes are characteristic associations of specific malignancies with various congenital anomalies. In addition to such diseases, an increased prevalence in general of chromosomal instability, malformations, immunodeficiencies, altered growth and development, and reproductive loss has been observed in both childhood leukemias and solid tumors. The overlap among these congenital disorders suggests their common prenatal, possibly genetic origin and thus the existence of a nonspecific genetic instability leading to various clinical manifestations of disturbancies in cell division. Seeking for related features in family members of a patient with malignancy may be of clinical value in detecting predisposition to cancer.

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalPathology and Oncology Research
Volume10
Issue number1
Publication statusPublished - 2004

Fingerprint

Neoplasms
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Chromosomal Instability
Growth and Development
Cell Division
Leukemia

Keywords

  • Cancer-prone diseases
  • Genetic instability
  • Mild errors of morphogenesis
  • Predisposition to cancer
  • Premature centromere division

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Clinical Manifestations of Genetic Instability Overlap One Another. / Méhes, K.; Kosztolányi, G.

In: Pathology and Oncology Research, Vol. 10, No. 1, 2004, p. 12-16.

Research output: Contribution to journalArticle

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