Clinical, histopathological, immunophenotypic and molecular analysis of 60 patients with cutaneous T-cell infiltrates with follow up of indeterminate cases to identify T-cell lymphoma

Nóra Eros, Zsuzsánna Károlyi, Márta Marschalkó, S. Kárpáti, A. Matolcsy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Diagnosis of primary cutaneous T-cell lymphomas, especially of mycosis fungoides could be difficult in early stage due to clinical and histopathological similarity to reactive inflammatory dermatoses. To assess diagnostic value of complex histological, immunophenotypic and T-cell receptor γ gene rearrangement analysis, skin biopsy specimen and peripheral blood samples of 60 patients with suspected cutaneous T-cell lymphoma were analyzed. Our results indicate clear distinction between reactive dermatoses (benign cases, n=31) and cutaneous T-cell lymphomas (lymphoma cases, n=17). As definite diagnosis was not obtained in a smaller group of patients (indeterminate cases, n=12), these patients were followed up. Repeated skin biopsy confirmed mycosis fungoides in 6/12 cases, however in 6/12 patients the diagnosis remained indeterminate. We concluded that careful and complex clinical follow up and repeated histopathological, immunophenotypic and molecular analysis is needed for an appropriate diagnosis in the assessment of early stage mycosis fungoides and uncertain clinical cases.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalPathology and Oncology Research
Volume14
Issue number1
DOIs
Publication statusPublished - Mar 2008

Fingerprint

T-Cell Lymphoma
Cutaneous T-Cell Lymphoma
Mycosis Fungoides
T-Lymphocytes
Skin
Skin Diseases
T-Lymphocyte Gene Rearrangement
Biopsy
T-Cell Receptor Genes
Lymphoma

Keywords

  • Cutaneous T-cell infiltrate
  • Cutaneous T-cell lymphoma
  • Histopathology
  • Immunophenotype
  • Molecular biology
  • Mycosis fungoides

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

@article{2305d8643a0349489b8b08dadf6c82a7,
title = "Clinical, histopathological, immunophenotypic and molecular analysis of 60 patients with cutaneous T-cell infiltrates with follow up of indeterminate cases to identify T-cell lymphoma",
abstract = "Diagnosis of primary cutaneous T-cell lymphomas, especially of mycosis fungoides could be difficult in early stage due to clinical and histopathological similarity to reactive inflammatory dermatoses. To assess diagnostic value of complex histological, immunophenotypic and T-cell receptor γ gene rearrangement analysis, skin biopsy specimen and peripheral blood samples of 60 patients with suspected cutaneous T-cell lymphoma were analyzed. Our results indicate clear distinction between reactive dermatoses (benign cases, n=31) and cutaneous T-cell lymphomas (lymphoma cases, n=17). As definite diagnosis was not obtained in a smaller group of patients (indeterminate cases, n=12), these patients were followed up. Repeated skin biopsy confirmed mycosis fungoides in 6/12 cases, however in 6/12 patients the diagnosis remained indeterminate. We concluded that careful and complex clinical follow up and repeated histopathological, immunophenotypic and molecular analysis is needed for an appropriate diagnosis in the assessment of early stage mycosis fungoides and uncertain clinical cases.",
keywords = "Cutaneous T-cell infiltrate, Cutaneous T-cell lymphoma, Histopathology, Immunophenotype, Molecular biology, Mycosis fungoides",
author = "N{\'o}ra Eros and Zsuzs{\'a}nna K{\'a}rolyi and M{\'a}rta Marschalk{\'o} and S. K{\'a}rp{\'a}ti and A. Matolcsy",
year = "2008",
month = "3",
doi = "10.1007/s12253-008-9014-3",
language = "English",
volume = "14",
pages = "63--67",
journal = "Pathology and Oncology Research",
issn = "1219-4956",
publisher = "Springer Netherlands",
number = "1",

}

TY - JOUR

T1 - Clinical, histopathological, immunophenotypic and molecular analysis of 60 patients with cutaneous T-cell infiltrates with follow up of indeterminate cases to identify T-cell lymphoma

AU - Eros, Nóra

AU - Károlyi, Zsuzsánna

AU - Marschalkó, Márta

AU - Kárpáti, S.

AU - Matolcsy, A.

PY - 2008/3

Y1 - 2008/3

N2 - Diagnosis of primary cutaneous T-cell lymphomas, especially of mycosis fungoides could be difficult in early stage due to clinical and histopathological similarity to reactive inflammatory dermatoses. To assess diagnostic value of complex histological, immunophenotypic and T-cell receptor γ gene rearrangement analysis, skin biopsy specimen and peripheral blood samples of 60 patients with suspected cutaneous T-cell lymphoma were analyzed. Our results indicate clear distinction between reactive dermatoses (benign cases, n=31) and cutaneous T-cell lymphomas (lymphoma cases, n=17). As definite diagnosis was not obtained in a smaller group of patients (indeterminate cases, n=12), these patients were followed up. Repeated skin biopsy confirmed mycosis fungoides in 6/12 cases, however in 6/12 patients the diagnosis remained indeterminate. We concluded that careful and complex clinical follow up and repeated histopathological, immunophenotypic and molecular analysis is needed for an appropriate diagnosis in the assessment of early stage mycosis fungoides and uncertain clinical cases.

AB - Diagnosis of primary cutaneous T-cell lymphomas, especially of mycosis fungoides could be difficult in early stage due to clinical and histopathological similarity to reactive inflammatory dermatoses. To assess diagnostic value of complex histological, immunophenotypic and T-cell receptor γ gene rearrangement analysis, skin biopsy specimen and peripheral blood samples of 60 patients with suspected cutaneous T-cell lymphoma were analyzed. Our results indicate clear distinction between reactive dermatoses (benign cases, n=31) and cutaneous T-cell lymphomas (lymphoma cases, n=17). As definite diagnosis was not obtained in a smaller group of patients (indeterminate cases, n=12), these patients were followed up. Repeated skin biopsy confirmed mycosis fungoides in 6/12 cases, however in 6/12 patients the diagnosis remained indeterminate. We concluded that careful and complex clinical follow up and repeated histopathological, immunophenotypic and molecular analysis is needed for an appropriate diagnosis in the assessment of early stage mycosis fungoides and uncertain clinical cases.

KW - Cutaneous T-cell infiltrate

KW - Cutaneous T-cell lymphoma

KW - Histopathology

KW - Immunophenotype

KW - Molecular biology

KW - Mycosis fungoides

UR - http://www.scopus.com/inward/record.url?scp=49349107950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49349107950&partnerID=8YFLogxK

U2 - 10.1007/s12253-008-9014-3

DO - 10.1007/s12253-008-9014-3

M3 - Article

C2 - 18392954

AN - SCOPUS:49349107950

VL - 14

SP - 63

EP - 67

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

SN - 1219-4956

IS - 1

ER -