A corticobasalis degeneráció diagnózisának ismérvei.

Translated title of the contribution: Clinical features of corticobasal degeneration

Marianna Farsang, Annamária Takáts, I. Szirmai, T. Kovács

Research output: Contribution to journalArticle

Abstract

Corticobasal degeneration was described in 1968 by Rebeiz, Kolodny and Richardson, who characterized the disease as a syndrome of asymmetric akinesis and rigidity, dystonia of the upper limb, apraxia, myoclonus and dementia. Atrophy of the frontal and parietal lobe, neuronal loss, gliosis and achromatic neurones (and nowadays astrocytic plaques) are the characteristic pathological features of the disease. Corticobasal degeneration is a rare or a rarely recognized disease and it is frequently misdiagnosed as Parkinson's disease. According to the Lang's criteria, corticobasal degeneration can be diagnosed in the presence of rigidity and one cortical symptom (apraxia, cortical sensory loss, alien hand) or in a patient with rigidity, dystonia and focal reflex myoclonus. Exclusion criteria are early dementia (as in primary degenerative dementias), early vertical gaze problems (as in progressive supranuclear palsy), resting tremor and good, sustained therapeutic response to levodopa (as in Parkinson's disease), severe autonomic problems (as in multiple system atrophy) and any pathology on imaging studies which might explain the clinical symptoms. It should be mentioned, that recently early dementia is recognized as an initial symptom of corticobasal degeneration. The authors present a case and review the literature to call attention to this disorder.

Original languageHungarian
Pages (from-to)45-51
Number of pages7
JournalIdeggyógyászati szemle
Volume58
Issue number1-2
Publication statusPublished - Jan 20 2005

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Dementia
Apraxias
Myoclonus
Parkinson Disease
Progressive Supranuclear Palsy
Multiple System Atrophy
Dystonic Disorders
Parietal Lobe
Gliosis
Dystonia
Levodopa
Frontal Lobe
Tremor
Diagnostic Errors
Upper Extremity
Atrophy
Reflex
Hand
Pathology
Neurons

ASJC Scopus subject areas

  • Medicine(all)

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A corticobasalis degeneráció diagnózisának ismérvei. / Farsang, Marianna; Takáts, Annamária; Szirmai, I.; Kovács, T.

In: Ideggyógyászati szemle, Vol. 58, No. 1-2, 20.01.2005, p. 45-51.

Research output: Contribution to journalArticle

Farsang, Marianna ; Takáts, Annamária ; Szirmai, I. ; Kovács, T. / A corticobasalis degeneráció diagnózisának ismérvei. In: Ideggyógyászati szemle. 2005 ; Vol. 58, No. 1-2. pp. 45-51.
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