Anti-SRP-pozitív myositises betegeink klinikai sajátosságai és terápiára adott válaszuk

Translated title of the contribution: Clinical features and therapeutic response of our anti-SRP positive patients with myositis

Botos Balázs, Nagy Vincze Melinda, K. Dankó

Research output: Contribution to journalArticle

Abstract

Introduction: Idiopathic inflammatory myopathies are a group of clinically heterogeneous diseases, which have been classified by myositis specific antibodies recently. The anti-SRP positive subset of this group is characterized by more severe clinical prognosis than other myositis specific antibody positive types. Aim: Our goal was to compare 16 anti-SRP positive patients in the Division of Clinical Immunology, Department of Internal Medicine, University of Debrecen with 16 antibody negative ones. Method: Muscle strength validated in both groups by the manual muscle test proved to be significantly decreased both before and after therapy (χ2 = 0.006 and 0.019) in the anti-SRP positive group. Results: Muscle-specific inflammatory laboratory parameters showed significant difference only in case of LDH-levels after therapy. Both groups showed good clinical response to first line steroid treatment, yet the significantly higher rate of second line administration suggests worse therapeutic response of the antibody positive group. Conclusion: Based on these facts we determined poor clinical prognosis and therapeutic response of the anti-SRP positive group.

Original languageHungarian
Pages (from-to)1382-1389
Number of pages8
JournalOrvosi Hetilap
Volume158
Issue number35
DOIs
Publication statusPublished - Sep 1 2017

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Myositis
Antibodies
Therapeutics
Muscles
Muscle Strength
Internal Medicine
Allergy and Immunology
Antibody Formation
Steroids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anti-SRP-pozitív myositises betegeink klinikai sajátosságai és terápiára adott válaszuk. / Balázs, Botos; Melinda, Nagy Vincze; Dankó, K.

In: Orvosi Hetilap, Vol. 158, No. 35, 01.09.2017, p. 1382-1389.

Research output: Contribution to journalArticle

Balázs, Botos ; Melinda, Nagy Vincze ; Dankó, K. / Anti-SRP-pozitív myositises betegeink klinikai sajátosságai és terápiára adott válaszuk. In: Orvosi Hetilap. 2017 ; Vol. 158, No. 35. pp. 1382-1389.
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