Clinical experiences with Creutzfeldt-Jakob disease

Three case studies

A. Szűcs, Péter Várallyay, Éva Osztie, Erzsébet Papp, András Sólyom, Lehel Finta, Dániel Varga, Gábor Barcs, András Holló, A. Kamondi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The clinical picture, electroencephalographic, imaging and cerebrospinal fluid parameters as well as the molecular background of Creutzfeldt-Jakob disease have been well explored. The diagnostic criteria, offering clinicians a fair chance to identify these patients in vivo, have recently been updated. However, the diagnosis is still a challenge in everyday neurological routine. We report on three of our Creutzfeldt-Jakob patients for calling attention to the classical and the recently defined features of the disease. We conclude that based on the rapidly progressing neuropsychiatrie syndrome Creutzfeldt-Jakob disease may be suspected; follow-up EEG may reveal the typical (pseudo)-periodic pattern with progressive deterioration of the background activity. In addition, diffusion-weighted brain MRI imaging (DWI) has high diagnostic value. Detection of 14-3-3 protein in the cerebrospinal fluid supports the in vivo diagnosis.

Original languageEnglish
Pages (from-to)401-410
Number of pages10
JournalIdeggyógyászati szemle
Volume65
Issue number11-12
Publication statusPublished - Nov 30 2012

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Creutzfeldt-Jakob Syndrome
Cerebrospinal Fluid
14-3-3 Proteins
Diffusion Magnetic Resonance Imaging
Neuroimaging
Electroencephalography

Keywords

  • CJD
  • Diffusion MRI
  • Periodic EEG
  • Prion

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Szűcs, A., Várallyay, P., Osztie, É., Papp, E., Sólyom, A., Finta, L., ... Kamondi, A. (2012). Clinical experiences with Creutzfeldt-Jakob disease: Three case studies. Ideggyógyászati szemle, 65(11-12), 401-410.

Clinical experiences with Creutzfeldt-Jakob disease : Three case studies. / Szűcs, A.; Várallyay, Péter; Osztie, Éva; Papp, Erzsébet; Sólyom, András; Finta, Lehel; Varga, Dániel; Barcs, Gábor; Holló, András; Kamondi, A.

In: Ideggyógyászati szemle, Vol. 65, No. 11-12, 30.11.2012, p. 401-410.

Research output: Contribution to journalArticle

Szűcs, A, Várallyay, P, Osztie, É, Papp, E, Sólyom, A, Finta, L, Varga, D, Barcs, G, Holló, A & Kamondi, A 2012, 'Clinical experiences with Creutzfeldt-Jakob disease: Three case studies', Ideggyógyászati szemle, vol. 65, no. 11-12, pp. 401-410.
Szűcs A, Várallyay P, Osztie É, Papp E, Sólyom A, Finta L et al. Clinical experiences with Creutzfeldt-Jakob disease: Three case studies. Ideggyógyászati szemle. 2012 Nov 30;65(11-12):401-410.
Szűcs, A. ; Várallyay, Péter ; Osztie, Éva ; Papp, Erzsébet ; Sólyom, András ; Finta, Lehel ; Varga, Dániel ; Barcs, Gábor ; Holló, András ; Kamondi, A. / Clinical experiences with Creutzfeldt-Jakob disease : Three case studies. In: Ideggyógyászati szemle. 2012 ; Vol. 65, No. 11-12. pp. 401-410.
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