Clinical experiences with Creutzfeldt-Jakob disease: Three case studies

Anna Szucs, Péter Várallyay, Éva Osztie, Erzsébet Papp, András Sólyom, Lehel Finta, Dániel Varga, Gábor Barcs, András Holló, Anita Kamondi

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1 Citation (Scopus)


The clinical picture, electroencephalographic, imaging and cerebrospinal fluid parameters as well as the molecular background of Creutzfeldt-Jakob disease have been well explored. The diagnostic criteria, offering clinicians a fair chance to identify these patients in vivo, have recently been updated. However, the diagnosis is still a challenge in everyday neurological routine. We report on three of our Creutzfeldt-Jakob patients for calling attention to the classical and the recently defined features of the disease. We conclude that based on the rapidly progressing neuropsychiatrie syndrome Creutzfeldt-Jakob disease may be suspected; follow-up EEG may reveal the typical (pseudo)-periodic pattern with progressive deterioration of the background activity. In addition, diffusion-weighted brain MRI imaging (DWI) has high diagnostic value. Detection of 14-3-3 protein in the cerebrospinal fluid supports the in vivo diagnosis.

Original languageEnglish
Pages (from-to)401-410
Number of pages10
JournalIdeggyogyaszati szemle
Issue number11-12
Publication statusPublished - Nov 30 2012


  • CJD
  • Diffusion MRI
  • Periodic EEG
  • Prion

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Szucs, A., Várallyay, P., Osztie, É., Papp, E., Sólyom, A., Finta, L., Varga, D., Barcs, G., Holló, A., & Kamondi, A. (2012). Clinical experiences with Creutzfeldt-Jakob disease: Three case studies. Ideggyogyaszati szemle, 65(11-12), 401-410.