Kétféle parathormonmérési módszer klinikai értékének vizsgálata krónikus veseelégtelenségben a D-vitamin-ellátottság figyelembevételével

Translated title of the contribution: Clinical evaluation of two parathyroid hormone assays in the context of vitamin D supply in chronic kidney disease

László Kovács, Éva Virágh, Dóra Balogh, Bernadette Kálmán, Zoltán Locsei, Erzsébet Toldy

Research output: Contribution to journalArticle

Abstract

Introduction: Parathyroid hormone levels provide important information in chronic renal failure. Aim: To compare parathyroid hormone levels measured by two assays in correlation with vitamin D supply. Method: Parathyroid hormone and 25-hydroxi-vitamin-D were determined in 104 patients (31 patients with chronic renal failure without renal replacement therapy, 36 patients treated with peritoneal dialysis and 37 patients treated with hemodialysis). Results: Good correlation was found between results of the two parathyroid hormone methods, but the intact parathyroid hormone levels were higher than the biointact values. 87% and 13% of the patients had vitamin-D deficiency and insufficiency, respectively. The frequency of serious vitamin-D deficiency was higher in the peritoneal dialysis than in the hemodialysis group. Intact parathyroid hormone levels were different in dialysed patients having vitamin-D-deficiency and insufficiency, and the difference was higher for the biointact than intact values. Negative correlation was detected between biointact parathyroid hormone and 25-hydroxivitamin-D in the hemodialysis group. Conclusions: Biointact parathyroid hormone levels better reflect the vitamin D supply and bone metabolism than intact levels, especially in hemodialysed patients.

Translated title of the contributionClinical evaluation of two parathyroid hormone assays in the context of vitamin D supply in chronic kidney disease
Original languageHungarian
Pages (from-to)2025-2036
Number of pages12
JournalOrvosi hetilap
Volume154
Issue number51
DOIs
Publication statusPublished - Dec 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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