A renin-aldoszteron rendszer vizsgálata két módszerrel különbözo klinikai állapotokban

Translated title of the contribution: Clinical evaluation of the renin-aldosterone system: Comparison of two methods in different clinical conditions

Dóra Horváth, Zoltán Locsei, Zsuzsanna Csizmadia, Erzsébet Toldy, I. Szabolcs, K. Rácz

Research output: Contribution to journalArticle

Abstract

Introduction: Measurement of plasma aldosterone/renin ratio is the key step in the diagnosis of primary aldosteronism. Aim: The aim of the authors was to analyze and compare the diagnostic utility of plasma aldosterone/renin activity and plasma aldosterone/renin concentration ratios. Methods: Plasma aldosterone and plasma renin activity were determined by radioimmunoassays and plasma renin concentration was measured by immunoradiometric assay in 134 subjects (80 women and 54 men, aged 46±15.5 years) including 49 healthy blood donors (control group), 59 patients with hypertension (25 treated and 34 untreated) and 26 patients with incidentally discovered adrenal adenomas. Results: There was a weak correlation (r = 0.59) between plasma renin activity and plasma renin concentration in the lower range (plasma renin activity, 0.63±0.41 ng/ml/h; plasma renin concentration, 8.1±4.9 ng/l). Considering the cut-off value of plasma aldosterone/renin ratios determined in controls (plasma aldosterone/renin activity ratio, 30 ng/dl/ng/ml/h; plasma aldosterone/renin concentration ratio, 3.0 ng/dl/ng/l), high proportion of falsely positive results were found among patients on beta-receptor blocker therapy (plasma aldosterone/renin activity ratio, 22.2%; plasma aldosterone/renin concentration ratio, 44.4%) Conclusion: The widely used plasma aldosterone/renin activity ratio can only be replaced with plasma aldosterone/renin concentration ratio with precaution on different clinical conditions.

Original languageHungarian
Pages (from-to)1701-1710
Number of pages10
JournalOrvosi Hetilap
Volume153
Issue number43
DOIs
Publication statusPublished - Oct 1 2012

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Aldosterone
Renin
Immunoradiometric Assay
Hyperaldosteronism
Blood Donors
Adenoma
Radioimmunoassay

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A renin-aldoszteron rendszer vizsgálata két módszerrel különbözo klinikai állapotokban. / Horváth, Dóra; Locsei, Zoltán; Csizmadia, Zsuzsanna; Toldy, Erzsébet; Szabolcs, I.; Rácz, K.

In: Orvosi Hetilap, Vol. 153, No. 43, 01.10.2012, p. 1701-1710.

Research output: Contribution to journalArticle

Horváth, Dóra ; Locsei, Zoltán ; Csizmadia, Zsuzsanna ; Toldy, Erzsébet ; Szabolcs, I. ; Rácz, K. / A renin-aldoszteron rendszer vizsgálata két módszerrel különbözo klinikai állapotokban. In: Orvosi Hetilap. 2012 ; Vol. 153, No. 43. pp. 1701-1710.
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abstract = "Introduction: Measurement of plasma aldosterone/renin ratio is the key step in the diagnosis of primary aldosteronism. Aim: The aim of the authors was to analyze and compare the diagnostic utility of plasma aldosterone/renin activity and plasma aldosterone/renin concentration ratios. Methods: Plasma aldosterone and plasma renin activity were determined by radioimmunoassays and plasma renin concentration was measured by immunoradiometric assay in 134 subjects (80 women and 54 men, aged 46±15.5 years) including 49 healthy blood donors (control group), 59 patients with hypertension (25 treated and 34 untreated) and 26 patients with incidentally discovered adrenal adenomas. Results: There was a weak correlation (r = 0.59) between plasma renin activity and plasma renin concentration in the lower range (plasma renin activity, 0.63±0.41 ng/ml/h; plasma renin concentration, 8.1±4.9 ng/l). Considering the cut-off value of plasma aldosterone/renin ratios determined in controls (plasma aldosterone/renin activity ratio, 30 ng/dl/ng/ml/h; plasma aldosterone/renin concentration ratio, 3.0 ng/dl/ng/l), high proportion of falsely positive results were found among patients on beta-receptor blocker therapy (plasma aldosterone/renin activity ratio, 22.2{\%}; plasma aldosterone/renin concentration ratio, 44.4{\%}) Conclusion: The widely used plasma aldosterone/renin activity ratio can only be replaced with plasma aldosterone/renin concentration ratio with precaution on different clinical conditions.",
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AU - Locsei, Zoltán

AU - Csizmadia, Zsuzsanna

AU - Toldy, Erzsébet

AU - Szabolcs, I.

AU - Rácz, K.

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N2 - Introduction: Measurement of plasma aldosterone/renin ratio is the key step in the diagnosis of primary aldosteronism. Aim: The aim of the authors was to analyze and compare the diagnostic utility of plasma aldosterone/renin activity and plasma aldosterone/renin concentration ratios. Methods: Plasma aldosterone and plasma renin activity were determined by radioimmunoassays and plasma renin concentration was measured by immunoradiometric assay in 134 subjects (80 women and 54 men, aged 46±15.5 years) including 49 healthy blood donors (control group), 59 patients with hypertension (25 treated and 34 untreated) and 26 patients with incidentally discovered adrenal adenomas. Results: There was a weak correlation (r = 0.59) between plasma renin activity and plasma renin concentration in the lower range (plasma renin activity, 0.63±0.41 ng/ml/h; plasma renin concentration, 8.1±4.9 ng/l). Considering the cut-off value of plasma aldosterone/renin ratios determined in controls (plasma aldosterone/renin activity ratio, 30 ng/dl/ng/ml/h; plasma aldosterone/renin concentration ratio, 3.0 ng/dl/ng/l), high proportion of falsely positive results were found among patients on beta-receptor blocker therapy (plasma aldosterone/renin activity ratio, 22.2%; plasma aldosterone/renin concentration ratio, 44.4%) Conclusion: The widely used plasma aldosterone/renin activity ratio can only be replaced with plasma aldosterone/renin concentration ratio with precaution on different clinical conditions.

AB - Introduction: Measurement of plasma aldosterone/renin ratio is the key step in the diagnosis of primary aldosteronism. Aim: The aim of the authors was to analyze and compare the diagnostic utility of plasma aldosterone/renin activity and plasma aldosterone/renin concentration ratios. Methods: Plasma aldosterone and plasma renin activity were determined by radioimmunoassays and plasma renin concentration was measured by immunoradiometric assay in 134 subjects (80 women and 54 men, aged 46±15.5 years) including 49 healthy blood donors (control group), 59 patients with hypertension (25 treated and 34 untreated) and 26 patients with incidentally discovered adrenal adenomas. Results: There was a weak correlation (r = 0.59) between plasma renin activity and plasma renin concentration in the lower range (plasma renin activity, 0.63±0.41 ng/ml/h; plasma renin concentration, 8.1±4.9 ng/l). Considering the cut-off value of plasma aldosterone/renin ratios determined in controls (plasma aldosterone/renin activity ratio, 30 ng/dl/ng/ml/h; plasma aldosterone/renin concentration ratio, 3.0 ng/dl/ng/l), high proportion of falsely positive results were found among patients on beta-receptor blocker therapy (plasma aldosterone/renin activity ratio, 22.2%; plasma aldosterone/renin concentration ratio, 44.4%) Conclusion: The widely used plasma aldosterone/renin activity ratio can only be replaced with plasma aldosterone/renin concentration ratio with precaution on different clinical conditions.

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