Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking

P. Nagy, Ching Chien Chang, Daniel B. Shapiro, Diana Patricia Bernal, Carlene W. Elsner, Dorothy Mitchell-Leef, Andrew A. Toledo, Hilton I. Kort

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Objective: To evaluate the efficiency of oocyte donation cycles using egg "cryo-banking.". Design: Study conditions for vitrified/warmed oocytes for 20 non-autologous recipients (from 10 donors) were set prospectively, and outcomes of it were later compared retrospectively to nine fresh donations cycles. Setting: Private assisted reproductive technology program. Patient(s): Ten donors and 20 infertile recipients. Intervention(s): Oocytes were vitrified 3 to 4 hours after collection and cryo-stored. Intracytoplasmic sperm injection was performed 3 hours after warming, and embryos were in vitro cultured for 5 days. Two or three blastocysts were transferred per patient. Main Outcome Measure(s): Oocyte survival, fertilization, development, clinical pregnancy, and implantation rates. Result(s): A total of 153 oocytes were warmed and 134 survived. A total of 117 fertilized and 68% developed to blastocyst stage. A total of 47 embryos were transferred (2.35 embryos per recipient) and 26 implanted. Fifteen patients achieved ongoing pregnancies initially, and two additional pregnancies were obtained after transfer of supernumerary vitrified/warmed embryos. Nine of the 10 donors from the current study had previous fresh donations cycles from where seven clinical pregnancies were established in nine recipients, providing the base for comparison. Conclusion(s): Oocyte donation using vitrified/warmed oocytes can provide high pregnancy and implantation rates, and thus can be considered as efficient treatment procedure with additional benefits to recipients.

Original languageEnglish
Pages (from-to)520-526
Number of pages7
JournalFertility and Sterility
Volume92
Issue number2
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Oocyte Donation
Oocytes
Ovum
Embryonic Structures
Tissue Donors
Blastocyst
Pregnancy Rate
Pregnancy
Assisted Reproductive Techniques
Intracytoplasmic Sperm Injections
Fertilization
Outcome Assessment (Health Care)

Keywords

  • cryopreservation
  • donation
  • embryo
  • fertilization
  • implantation
  • Oocyte
  • pregnancy
  • vitrification

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Nagy, P., Chang, C. C., Shapiro, D. B., Bernal, D. P., Elsner, C. W., Mitchell-Leef, D., ... Kort, H. I. (2009). Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking. Fertility and Sterility, 92(2), 520-526. https://doi.org/10.1016/j.fertnstert.2008.06.005

Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking. / Nagy, P.; Chang, Ching Chien; Shapiro, Daniel B.; Bernal, Diana Patricia; Elsner, Carlene W.; Mitchell-Leef, Dorothy; Toledo, Andrew A.; Kort, Hilton I.

In: Fertility and Sterility, Vol. 92, No. 2, 08.2009, p. 520-526.

Research output: Contribution to journalArticle

Nagy, P, Chang, CC, Shapiro, DB, Bernal, DP, Elsner, CW, Mitchell-Leef, D, Toledo, AA & Kort, HI 2009, 'Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking', Fertility and Sterility, vol. 92, no. 2, pp. 520-526. https://doi.org/10.1016/j.fertnstert.2008.06.005
Nagy, P. ; Chang, Ching Chien ; Shapiro, Daniel B. ; Bernal, Diana Patricia ; Elsner, Carlene W. ; Mitchell-Leef, Dorothy ; Toledo, Andrew A. ; Kort, Hilton I. / Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking. In: Fertility and Sterility. 2009 ; Vol. 92, No. 2. pp. 520-526.
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