Clinical Evaluation of an Enamel Matrix Protein Derivative (Emdogain) Combined with a Bovine-Derived Xenograft (Bio-Oss) for the Treatment of lntrabony Periodontal Defects in Humans

Anton Sculean, Giovanni Carlo Chiantella, Péter Windisch, István Gera, Elmar Reich

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The purpose of the present study was to compare the treatment of deep intrabony defects with a combination of an enamel matrix protein derivative (EMD; Emdogain) and a bovine-derived xenograft (BDX; Bio-Oss) to BDX alone. Twenty-four healthy patients, each of whom displayed one intrabony defect, were randomly treated with a combination of EMD + BDX (test) or with BDX alone (control). Soft tissue measurements were made at baseline and 1 year following the therapy. No differences in any of the investigated parameters were observed at baseline between the two groups. No adverse healing response was observed in any of the patients. At 1 year after therapy, the sites treated with EMD + BDX showed a reduction in probing pocket depth (PPD) from 10.0 ± 1.5 mm to 4.3 ± 1.4 mm and a change in clinical attachment level (CAL) from 10.9 ± 2.0 mm to 6.2 ± 1.9 mm (P < .0001). In the group treated with BDX, the PPD was reduced from 9.7 ± 2.4 mm to 3.2 ± 0.7 mm and the CAL changed from 10.1 ± 2.3 mm to 5.2 ± 1.2 mm (P < .0001). Hard tissue fill was observed radiographicaily in all defects. Both treatments resulted in significant improvements of PPD and CAL. However, no statistically significant differences in any of the investigated parameters were observed between the test and control groups. Both therapies led to significant improvements of the investigated clinical parameters.

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalInternational Journal of Periodontics and Restorative Dentistry
Volume22
Issue number3
Publication statusPublished - Jun 1 2002

ASJC Scopus subject areas

  • Oral Surgery
  • Periodontics

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