Clinical consequences of cardiovascular autonomic neuropathy in diabetic patients

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43 Citations (Scopus)

Abstract

A wide range of clinical consequences of cardiovascular autonomic neuropathy (CAN) can be observed in diabetic patients and contributes to the clinical picture of the diabetic heart. Resting heart rate and cardiovascular reflexes as well as circadian heart rate variability may be altered by CAN in diabetes. Moreover, blood pressure is also influenced by sympathovagal imbalance. Postural hypotension is a clinical characteristic in diabetic subjects with CAN. Painless myocardial infarction, ischaemia and left ventricular dysfunction are also observed in some cases. Impairment of cardiac parasympathetic and sympathetic innervation as well as QT-interval prolongation may play a partial role in the pathogenic mechanism of sudden unexpected death in diabetic patients. The risk of surgical intervention and that of anaesthesia are increased due to abnormal cardiovascular reactions. Clinical symptoms and signs of CAN should be assessed as severe diabetic complication and the therapy is difficult in some cases. Taken together, symptoms and signs of CAN carry a poor prognosis in diabetic patients.

Original languageEnglish
JournalActa Diabetologica
Volume40
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Dec 2003

Fingerprint

Diabetic Neuropathies
Signs and Symptoms
Heart Rate
Orthostatic Hypotension
Left Ventricular Dysfunction
Diabetes Complications
Sudden Death
Myocardial Ischemia
Reflex
Anesthesia
Myocardial Infarction
Blood Pressure
Therapeutics

Keywords

  • Autonomic neuropathy
  • Cardiovascular reflex tests
  • Diabetes mellitus
  • Postural hypotension
  • Sudden cardiac death

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Clinical consequences of cardiovascular autonomic neuropathy in diabetic patients. / Jermendy, G.

In: Acta Diabetologica, Vol. 40, No. SUPPL. 2, 12.2003.

Research output: Contribution to journalArticle

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