Clinical Aspects of Aconitum Preparations

Chi Jung Tai, Mohamed El-Shazly, Tung Ying Wu, Kun Tai Lee, Dezsö Csupor, Judit Hohmann, Fang Rong Chang, Yang Chang Wu

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Aconite species have played an important role in human history. Aconitum species have been used worldwide as poisons as well as remedies. Their potential in targeting several ailments such as pain, rheumatism, and lethargy has been recognized by Western, Chinese, and Indian health care practitioners. Aconite use in herbal preparations has declined, especially in Europe and the United States, in the first half of the twentieth century due to several reported toxicity cases. The situation has changed with the application of new technologies for the accurate analysis of its toxic components and the development of efficient detoxification protocols. Some Asian countries started small clinical trials to evaluate the potency and safety of different marketed aconite preparations. The current review summarizes therapeutic uses of aconite preparations in China, Taiwan, India, and Japan. It also highlights clinical trial results with special emphasis on their limitations. Modern drugs and pharmacopoeial preparations derived from aconite are also discussed.

Original languageEnglish
Pages (from-to)1017-1028
Number of pages12
JournalPlanta Medica
Volume81
Issue number12-13
DOIs
Publication statusPublished - Jul 10 2015

Keywords

  • Aconitum
  • Ayurvedic medicine
  • Ranunculaceae
  • fuzi
  • monkshood
  • traditional Chinese medicine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Tai, C. J., El-Shazly, M., Wu, T. Y., Lee, K. T., Csupor, D., Hohmann, J., Chang, F. R., & Wu, Y. C. (2015). Clinical Aspects of Aconitum Preparations. Planta Medica, 81(12-13), 1017-1028. https://doi.org/10.1055/s-0035-1546183