Clinical and model research of neurotrauma.

András Büki, Erzsébet Kövesdi, József Pál, Endre Czeiter

Research output: Contribution to journalArticle

Abstract

Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.

Original languageEnglish
Pages (from-to)41-55
Number of pages15
JournalMethods in molecular biology (Clifton, N.J.)
Volume566
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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