Clinical and model research of neurotrauma.

András Büki, Erzsébet Kövesdi, József Pál, Endre Czeiter

Research output: Contribution to journalArticle

Abstract

Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.

Original languageEnglish
Pages (from-to)41-55
Number of pages15
JournalMethods in molecular biology (Clifton, N.J.)
Volume566
DOIs
Publication statusPublished - 2009

Fingerprint

Research
Laboratory Animals
Pathologic Processes
Theoretical Models
Biomarkers
Traumatic Brain Injury
Wounds and Injuries

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Clinical and model research of neurotrauma. / Büki, András; Kövesdi, Erzsébet; Pál, József; Czeiter, Endre.

In: Methods in molecular biology (Clifton, N.J.), Vol. 566, 2009, p. 41-55.

Research output: Contribution to journalArticle

@article{210031a1393849d084f78874781f9118,
title = "Clinical and model research of neurotrauma.",
abstract = "Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.",
author = "Andr{\'a}s B{\"u}ki and Erzs{\'e}bet K{\"o}vesdi and J{\'o}zsef P{\'a}l and Endre Czeiter",
year = "2009",
doi = "10.1007/978-1-59745-562-6_3",
language = "English",
volume = "566",
pages = "41--55",
journal = "Methods in Molecular Biology",
issn = "1064-3745",
publisher = "Humana Press",

}

TY - JOUR

T1 - Clinical and model research of neurotrauma.

AU - Büki, András

AU - Kövesdi, Erzsébet

AU - Pál, József

AU - Czeiter, Endre

PY - 2009

Y1 - 2009

N2 - Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.

AB - Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.

UR - http://www.scopus.com/inward/record.url?scp=77449158540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77449158540&partnerID=8YFLogxK

U2 - 10.1007/978-1-59745-562-6_3

DO - 10.1007/978-1-59745-562-6_3

M3 - Article

VL - 566

SP - 41

EP - 55

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

SN - 1064-3745

ER -