Clinical and model research of neurotrauma

András Büki, Erzsébet Kövesdi, József Pál, Endre Czeiter

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.

Original languageEnglish
Title of host publicationNeuroproteomics
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages41-55
Number of pages15
ISBN (Print)9781934115848
DOIs
Publication statusPublished - Jan 1 2009

Publication series

NameMethods in Molecular Biology
Volume566
ISSN (Print)1064-3745

Keywords

  • Biomarkers
  • Diffuse axonal injury
  • Fluid percussion
  • Focal injury,
  • Impact acceleration
  • Intracranial pressure
  • Secondary injury
  • Traumatic brain injury

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Büki, A., Kövesdi, E., Pál, J., & Czeiter, E. (2009). Clinical and model research of neurotrauma. In Neuroproteomics: Methods and Protocols (pp. 41-55). (Methods in Molecular Biology; Vol. 566). Humana Press Inc.. https://doi.org/10.1007/978-1-59745-562-6_3