Clinical and laboratory studies of levamisole in patients with rheumatoid arthritis

Ahmed F. El-Ghobarey, Mayron E. Mavrikakis, Marion McLeod, Peter M G Reynolds, Hilary A. Capell, David G. Spencer, G. Bálint, J. Pierre Mathieu, T. McAllister, Anne Cooney, W. Carson Dick

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Two studies with levamisole in rheumatoid arthritis are reported. in the first study of 30 patients levamisole was superior to placebo in terms of pain relief, reduction in articular tenderness, duration of morning stiffness, erythrocyte sedimentation rate (esr), and radioisotope uptake in knee and wrist joints. there were no consistent differences in lymphocyte function, immunoglobin or complement concentration, or polymorphonuclear granulocytic function. in the second study forty patients were commenced on treatment with either gold or levamisole. at the end of one year there were significant improvements with both regimens in pain score, joint tenderness and esr. the patients on levamisole showed significant improvement of duration of morning stiffness, while the patients on gold showed significant improvement of rheumatoid factor titre and left hand grip, but there were no significant differences between the two regimens.

Original languageEnglish
Pages (from-to)385-400
Number of pages16
JournalQJM - Monthly Journal of the Association of Physicians
Volume47
Issue number3
DOIs
Publication statusPublished - 1978

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Levamisole
Rheumatoid Arthritis
Blood Sedimentation
Gold
Wrist Joint
Rheumatoid Factor
Arthralgia
Hand Strength
Knee Joint
Radioisotopes
Hand
Joints
Placebos
Lymphocytes
Pain
Clinical Studies
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

El-Ghobarey, A. F., Mavrikakis, M. E., McLeod, M., Reynolds, P. M. G., Capell, H. A., Spencer, D. G., ... Dick, W. C. (1978). Clinical and laboratory studies of levamisole in patients with rheumatoid arthritis. QJM - Monthly Journal of the Association of Physicians, 47(3), 385-400. https://doi.org/10.1093/oxfordjournals.qjmed.a067548

Clinical and laboratory studies of levamisole in patients with rheumatoid arthritis. / El-Ghobarey, Ahmed F.; Mavrikakis, Mayron E.; McLeod, Marion; Reynolds, Peter M G; Capell, Hilary A.; Spencer, David G.; Bálint, G.; Mathieu, J. Pierre; McAllister, T.; Cooney, Anne; Dick, W. Carson.

In: QJM - Monthly Journal of the Association of Physicians, Vol. 47, No. 3, 1978, p. 385-400.

Research output: Contribution to journalArticle

El-Ghobarey, AF, Mavrikakis, ME, McLeod, M, Reynolds, PMG, Capell, HA, Spencer, DG, Bálint, G, Mathieu, JP, McAllister, T, Cooney, A & Dick, WC 1978, 'Clinical and laboratory studies of levamisole in patients with rheumatoid arthritis', QJM - Monthly Journal of the Association of Physicians, vol. 47, no. 3, pp. 385-400. https://doi.org/10.1093/oxfordjournals.qjmed.a067548
El-Ghobarey, Ahmed F. ; Mavrikakis, Mayron E. ; McLeod, Marion ; Reynolds, Peter M G ; Capell, Hilary A. ; Spencer, David G. ; Bálint, G. ; Mathieu, J. Pierre ; McAllister, T. ; Cooney, Anne ; Dick, W. Carson. / Clinical and laboratory studies of levamisole in patients with rheumatoid arthritis. In: QJM - Monthly Journal of the Association of Physicians. 1978 ; Vol. 47, No. 3. pp. 385-400.
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