Klinikai és hisztopatológiai eredmények elorehaladott rectumtumorok neoadjuváns kezelése után

Translated title of the contribution: Clinical and histopathological results after the neo-adjuvant treatment of advanced rectal tumors

László Varga, Gellért Baradnay, József Hohn, Zsolt Simonka, Katalin Hideghéthy, Anikó Maráz, Alíz Nikolényi, Blanka Veréb, László Tiszlavicz, István Németh, Eszter Mán, György Lázár

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The role of the surgical intervention is decisive in treating colorectal tumors. The neo-adjuvant radio-chemotherapy has improved the efficacy of the treatment of advanced rectum tumors. In order to decrease the size and stage of advanced rectal carcinoma and to increase the rate of resecability, we introduced neoadjuvant radio-chemotherapy. We carried out neo-adjuvant and surgical treatment in case of 67 patients with rectal adenocarcinoma (T 2-4 N 1-2 M 0 ) between June 1, 2005 and July 31, 2008. The average age of the patients was 61.2 years, the division according to sex was 44 males/23 females. Regarding the local stage of the rectal process or the proximity to the sphincter, we applied radio-chemotherapy (radiotherapy 25 times altogether 45 Gy and on the first and last week for 5-5 days they received 350 mg/m 2 /day 5-FU and 20 mg/m 2 /day leucovorin chemotherapy, recently complemented with 3x1.8 Gy advanced boost radiation aiming at the macroscopic tumor site with security zone). Patients underwent surgery 8 weeks on average after restaging examinations. Thirty-eight patients underwent anterior rectal resection with double stapler procedure; there were 18 abdominoperineal rectal extirpations, 7 Hartmann operations and 4 per anum excisions. Compared to the preoperative staging, the histological evaluation of the resected specimens showed total remission (pT 0 N 0 ) in 11% and partial remission in 43%. The morbidity necessitating reoperation was 5.9%, without mortality and suture insufficiency. The long-term neo-adjuvant oncological treatment led to down-staging of rectal tumors in most cases and increased the resecability and rate of resection operations.

Translated title of the contributionClinical and histopathological results after the neo-adjuvant treatment of advanced rectal tumors
Original languageHungarian
Pages (from-to)129-135
Number of pages7
JournalMagyar onkologia
Volume54
Issue number2
DOIs
Publication statusPublished - Jun 1 2010

ASJC Scopus subject areas

  • Medicine(all)

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    Varga, L., Baradnay, G., Hohn, J., Simonka, Z., Hideghéthy, K., Maráz, A., Nikolényi, A., Veréb, B., Tiszlavicz, L., Németh, I., Mán, E., & Lázár, G. (2010). Klinikai és hisztopatológiai eredmények elorehaladott rectumtumorok neoadjuváns kezelése után. Magyar onkologia, 54(2), 129-135. https://doi.org/10.1556/MOnkol.54.2010.2.7