Clinical and histologic evaluation of granular beta-tricalcium phosphate for the treatment of human intrabony periodontal defects: A report on five cases

Andreas Stavropoulos, P. Windisch, Dora Szendröi-Kiss, Rosta Peter, I. Gera, Anton Sculean

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: The aim of the study is to clinically and histologically evaluate the healing of advanced intrabony defects treated with open flap debridement and the adjunct implantation of granular beta tricalcium phosphate (β-TCP). Methods: Five patients, each displaying advanced combined 1- and 2-wall intrabony defects around teeth scheduled for extraction or root resection, were recruited. Approximately 6 months after surgery, the teeth or roots were removed together with a portion of their surrounding soft and hard tissues and processed for histologic evaluation. Results: Themeanprobing depth (PD)was reduced from 10.8 ± 2.3 mm presurgically to 4.6 ± 2.1 mm, whereas a mean clinical attachment level (CAL) gain of 5.0 ± 0.7mmwas observed. The increase in gingival recession was 1.2 ± 3.2 mm. The histologic evaluation indicated the formation of newcellular cementumwith inserting collagen fibers to a varying extent (mean: 1.9 ± 0.7 mm; range: 1.2 to 3.03 mm) coronal to the most apical extent of the root instrumentation. The mean new bone formation was 1.0 ± 0.7 mm (range: 0.0 to 1.9 mm). In most specimens, β-TCP particles were embedded in the connective tissue,whereas the formation of a mineralized bone-like or cementum-like tissue around the particles was only occasionally observed. Conclusion: The present data indicates that treatment of intrabony periodontal defects with this β-TCP may result in substantial clinical improvements such as PD reduction and CAL gain, but this β-TCP does not seem to enhance the regeneration of cementum, periodontal ligament, and bone.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalJournal of Periodontology
Volume81
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Tooth Root
Dental Cementum
Gingival Recession
Bone and Bones
Tooth Extraction
Periodontal Ligament
Debridement
Osteogenesis
Connective Tissue
Regeneration
Collagen
Therapeutics
beta-tricalcium phosphate

Keywords

  • Bone graft(s)
  • Histology
  • Periodontal regeneration
  • Periodontitis

ASJC Scopus subject areas

  • Periodontics

Cite this

Clinical and histologic evaluation of granular beta-tricalcium phosphate for the treatment of human intrabony periodontal defects : A report on five cases. / Stavropoulos, Andreas; Windisch, P.; Szendröi-Kiss, Dora; Peter, Rosta; Gera, I.; Sculean, Anton.

In: Journal of Periodontology, Vol. 81, No. 2, 02.2010, p. 325-334.

Research output: Contribution to journalArticle

@article{c5b2d4fd70fb4fc8841f707651fa3b2b,
title = "Clinical and histologic evaluation of granular beta-tricalcium phosphate for the treatment of human intrabony periodontal defects: A report on five cases",
abstract = "Background: The aim of the study is to clinically and histologically evaluate the healing of advanced intrabony defects treated with open flap debridement and the adjunct implantation of granular beta tricalcium phosphate (β-TCP). Methods: Five patients, each displaying advanced combined 1- and 2-wall intrabony defects around teeth scheduled for extraction or root resection, were recruited. Approximately 6 months after surgery, the teeth or roots were removed together with a portion of their surrounding soft and hard tissues and processed for histologic evaluation. Results: Themeanprobing depth (PD)was reduced from 10.8 ± 2.3 mm presurgically to 4.6 ± 2.1 mm, whereas a mean clinical attachment level (CAL) gain of 5.0 ± 0.7mmwas observed. The increase in gingival recession was 1.2 ± 3.2 mm. The histologic evaluation indicated the formation of newcellular cementumwith inserting collagen fibers to a varying extent (mean: 1.9 ± 0.7 mm; range: 1.2 to 3.03 mm) coronal to the most apical extent of the root instrumentation. The mean new bone formation was 1.0 ± 0.7 mm (range: 0.0 to 1.9 mm). In most specimens, β-TCP particles were embedded in the connective tissue,whereas the formation of a mineralized bone-like or cementum-like tissue around the particles was only occasionally observed. Conclusion: The present data indicates that treatment of intrabony periodontal defects with this β-TCP may result in substantial clinical improvements such as PD reduction and CAL gain, but this β-TCP does not seem to enhance the regeneration of cementum, periodontal ligament, and bone.",
keywords = "Bone graft(s), Histology, Periodontal regeneration, Periodontitis",
author = "Andreas Stavropoulos and P. Windisch and Dora Szendr{\"o}i-Kiss and Rosta Peter and I. Gera and Anton Sculean",
year = "2010",
month = "2",
doi = "10.1902/jop.2009.090386",
language = "English",
volume = "81",
pages = "325--334",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "2",

}

TY - JOUR

T1 - Clinical and histologic evaluation of granular beta-tricalcium phosphate for the treatment of human intrabony periodontal defects

T2 - A report on five cases

AU - Stavropoulos, Andreas

AU - Windisch, P.

AU - Szendröi-Kiss, Dora

AU - Peter, Rosta

AU - Gera, I.

AU - Sculean, Anton

PY - 2010/2

Y1 - 2010/2

N2 - Background: The aim of the study is to clinically and histologically evaluate the healing of advanced intrabony defects treated with open flap debridement and the adjunct implantation of granular beta tricalcium phosphate (β-TCP). Methods: Five patients, each displaying advanced combined 1- and 2-wall intrabony defects around teeth scheduled for extraction or root resection, were recruited. Approximately 6 months after surgery, the teeth or roots were removed together with a portion of their surrounding soft and hard tissues and processed for histologic evaluation. Results: Themeanprobing depth (PD)was reduced from 10.8 ± 2.3 mm presurgically to 4.6 ± 2.1 mm, whereas a mean clinical attachment level (CAL) gain of 5.0 ± 0.7mmwas observed. The increase in gingival recession was 1.2 ± 3.2 mm. The histologic evaluation indicated the formation of newcellular cementumwith inserting collagen fibers to a varying extent (mean: 1.9 ± 0.7 mm; range: 1.2 to 3.03 mm) coronal to the most apical extent of the root instrumentation. The mean new bone formation was 1.0 ± 0.7 mm (range: 0.0 to 1.9 mm). In most specimens, β-TCP particles were embedded in the connective tissue,whereas the formation of a mineralized bone-like or cementum-like tissue around the particles was only occasionally observed. Conclusion: The present data indicates that treatment of intrabony periodontal defects with this β-TCP may result in substantial clinical improvements such as PD reduction and CAL gain, but this β-TCP does not seem to enhance the regeneration of cementum, periodontal ligament, and bone.

AB - Background: The aim of the study is to clinically and histologically evaluate the healing of advanced intrabony defects treated with open flap debridement and the adjunct implantation of granular beta tricalcium phosphate (β-TCP). Methods: Five patients, each displaying advanced combined 1- and 2-wall intrabony defects around teeth scheduled for extraction or root resection, were recruited. Approximately 6 months after surgery, the teeth or roots were removed together with a portion of their surrounding soft and hard tissues and processed for histologic evaluation. Results: Themeanprobing depth (PD)was reduced from 10.8 ± 2.3 mm presurgically to 4.6 ± 2.1 mm, whereas a mean clinical attachment level (CAL) gain of 5.0 ± 0.7mmwas observed. The increase in gingival recession was 1.2 ± 3.2 mm. The histologic evaluation indicated the formation of newcellular cementumwith inserting collagen fibers to a varying extent (mean: 1.9 ± 0.7 mm; range: 1.2 to 3.03 mm) coronal to the most apical extent of the root instrumentation. The mean new bone formation was 1.0 ± 0.7 mm (range: 0.0 to 1.9 mm). In most specimens, β-TCP particles were embedded in the connective tissue,whereas the formation of a mineralized bone-like or cementum-like tissue around the particles was only occasionally observed. Conclusion: The present data indicates that treatment of intrabony periodontal defects with this β-TCP may result in substantial clinical improvements such as PD reduction and CAL gain, but this β-TCP does not seem to enhance the regeneration of cementum, periodontal ligament, and bone.

KW - Bone graft(s)

KW - Histology

KW - Periodontal regeneration

KW - Periodontitis

UR - http://www.scopus.com/inward/record.url?scp=77649228044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649228044&partnerID=8YFLogxK

U2 - 10.1902/jop.2009.090386

DO - 10.1902/jop.2009.090386

M3 - Article

C2 - 20151813

AN - SCOPUS:77649228044

VL - 81

SP - 325

EP - 334

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 2

ER -