Clinical and biological heterogeneity of autoimmune myasthenia gravis

J. Pál, C. Rózsa, S. Komoly, Zsolt Illes

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Although myasthenia gravis (MG) has long been considered a well-established autoimmune disease associated with autoantibodies, which are convincingly pathogenic, accumulating data indicate both clinical and biological heterogeneity similar to many other putative autoimmune disorders. In a subset of patients, thymus plays a definite role: thymic autoimmunity results in generation of autoantibodies within the thymus, which cross-react with antigens at the neuromuscular junction, or thymoma leads to deficient central tolerance and impaired T cell selection. Heterogeneity on the autoantibody level may be associated with genetic heterogeneity and clinical phenotypes with different treatment responses.

Original languageEnglish
Pages (from-to)43-54
Number of pages12
JournalJournal of Neuroimmunology
Volume231
Issue number1-2
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Myasthenia Gravis
Autoantibodies
Thymus Gland
Central Tolerance
Thymoma
Genetic Heterogeneity
Neuromuscular Junction
Autoimmunity
Autoimmune Diseases
T-Lymphocytes
Phenotype
Antigens
Therapeutics

Keywords

  • Acethylcholine receptor
  • Acetylcholine
  • Antibodies
  • MuSK
  • Neuromuscular junction
  • Thymoma
  • Thymus

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Clinical and biological heterogeneity of autoimmune myasthenia gravis. / Pál, J.; Rózsa, C.; Komoly, S.; Illes, Zsolt.

In: Journal of Neuroimmunology, Vol. 231, No. 1-2, 02.2011, p. 43-54.

Research output: Contribution to journalArticle

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