Clinical and Biochemical Markers of Cardiovascular Structure and Function in Women with the Metabolic Syndrome

Gladys P. Velarde, Saadia Sherazi, D. Kraemer, Katia Bravo-Jaimes, Ryan Butterfield, Tonja Amico, Sherry D. Steinmetz, Maricela Guzman, Dale Martin, Sunita Dodani, Brian H. Smith

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The pathobiological impact of individual components of the metabolic syndrome (MS) on cardiac structural and functional parameters in women with isolated MS is not known. The objectives of this study were (1) to compare biochemical (prothrombotic, lipogenic, and inflammatory) and imaging (carotid intima-media thickening and basic cardiac structural measurements) markers in women with and without MS and (2) to examine if any of these markers associated or predicted cardiac structural differences between the 2 groups. This cross-sectional pilot study included 88 women with MS and 35 women without it. MS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Patients with diagnosis of diabetes were excluded. Compared with healthy subjects, women with MS had higher levels of intercellular adhesion molecule, myeloperoxidase, C-reactive protein, plasminogen activator inhibitor-1, leptin, apolipoprotein-B, and lower levels of apolipoprotein-A1 (p

Original languageEnglish
Pages (from-to)1705-1710
Number of pages6
JournalThe American journal of cardiology
Volume116
Issue number11
DOIs
Publication statusPublished - Dec 1 2015

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Biomarkers
Plasminogen Activator Inhibitor 1
Apolipoprotein A-I
Cell Adhesion Molecules
Apolipoproteins B
Leptin
C-Reactive Protein
Peroxidase
Healthy Volunteers
Cross-Sectional Studies
Cholesterol
Education
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Clinical and Biochemical Markers of Cardiovascular Structure and Function in Women with the Metabolic Syndrome. / Velarde, Gladys P.; Sherazi, Saadia; Kraemer, D.; Bravo-Jaimes, Katia; Butterfield, Ryan; Amico, Tonja; Steinmetz, Sherry D.; Guzman, Maricela; Martin, Dale; Dodani, Sunita; Smith, Brian H.

In: The American journal of cardiology, Vol. 116, No. 11, 01.12.2015, p. 1705-1710.

Research output: Contribution to journalArticle

Velarde, GP, Sherazi, S, Kraemer, D, Bravo-Jaimes, K, Butterfield, R, Amico, T, Steinmetz, SD, Guzman, M, Martin, D, Dodani, S & Smith, BH 2015, 'Clinical and Biochemical Markers of Cardiovascular Structure and Function in Women with the Metabolic Syndrome', The American journal of cardiology, vol. 116, no. 11, pp. 1705-1710. https://doi.org/10.1016/j.amjcard.2015.09.010
Velarde, Gladys P. ; Sherazi, Saadia ; Kraemer, D. ; Bravo-Jaimes, Katia ; Butterfield, Ryan ; Amico, Tonja ; Steinmetz, Sherry D. ; Guzman, Maricela ; Martin, Dale ; Dodani, Sunita ; Smith, Brian H. / Clinical and Biochemical Markers of Cardiovascular Structure and Function in Women with the Metabolic Syndrome. In: The American journal of cardiology. 2015 ; Vol. 116, No. 11. pp. 1705-1710.
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