Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity

Gábor Pintér, Ilona Bereczki, G. Batta, Réka Ötvös, F. Sztaricskai, Erzsébet Roth, Eszter Ostorházi, F. Rozgonyi, Lieve Naesens, Mariann Szarvas, Z. Boda, P. Herczegh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against Gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus.

Original languageEnglish
Pages (from-to)2713-2717
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number9
DOIs
Publication statusPublished - May 1 2010

Fingerprint

Ristocetin
H1N1 Subtype Influenza A Virus
Cycloaddition
Cycloaddition Reaction
Gram-Positive Bacteria
Glycosides
Viruses
Sugars
Antiviral Agents
Copper
Bacteria
Carbohydrates
Derivatives
ristocetin aglycon

Keywords

  • Anti-influenza virus
  • Antibacterial
  • Click reaction
  • Glycopeptide antibiotic
  • Ristocetin

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity. / Pintér, Gábor; Bereczki, Ilona; Batta, G.; Ötvös, Réka; Sztaricskai, F.; Roth, Erzsébet; Ostorházi, Eszter; Rozgonyi, F.; Naesens, Lieve; Szarvas, Mariann; Boda, Z.; Herczegh, P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 9, 01.05.2010, p. 2713-2717.

Research output: Contribution to journalArticle

Pintér, Gábor ; Bereczki, Ilona ; Batta, G. ; Ötvös, Réka ; Sztaricskai, F. ; Roth, Erzsébet ; Ostorházi, Eszter ; Rozgonyi, F. ; Naesens, Lieve ; Szarvas, Mariann ; Boda, Z. ; Herczegh, P. / Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 9. pp. 2713-2717.
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AU - Roth, Erzsébet

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