Cleft lip and palate: Etiology and prevention

E. Czeizel, Attila Vereczkey, F. Bánhidy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996 included 1374 cases with isolated cleft lip with or without cleft palate (CL ± CP) and 601 cases with isolated posterior cleft palate (CP) and their data were compared to 38,151 population controls without any defects and 20,750 malformed controls affected with isolated non-oral cleft defects. After the description of main features of these two oral cleft types, the results of etiological studies are summarized: there was association of high fever related influenza and common cold with secondary complications, angina pectoris, epilepsy related anticonvulsant drugs with higher risk of CL ± CP and CP, panic disorder with higher risk for CL ± CP and ampicillin for higher risk for CP. The Hungarian Periconception Service offered an opportunity to organize randomized double-blind controlled trial and controlled control trial for the evaluation of efficacy of periconceptional multivitamin (containing 0.8 mg folic acid) supplementation for the reduction of CL ± CP and CP. These trials did not indicate any preventive effect. However, the evaluation of the data set the Hungarian Case-Control Surveillance of Congenital Abnormalities showed a nearly 30% reduction in the first occurrence of CL ± CP and CP after the periconcepcional use of high doses (about 6 mg) folic acid. Thus there is a dose-dependent effect of folic acid in the prevention of oral clefts, therefore the present knowledge regarding the effect of folate and folic acid is also summarized.

Original languageEnglish
Title of host publicationCleft Lip and Palate: Etiology, Surgery and Repair and Sociopsychological Consequences
PublisherNova Science Publishers, Inc.
Pages1-53
Number of pages53
ISBN (Print)9781626187252
Publication statusPublished - Mar 2013

Fingerprint

Cleft Lip
Cleft Palate
Folic Acid
Defects
Ampicillin
Anticonvulsants
Association reactions
Common Cold
Population Control
Panic Disorder
Angina Pectoris
Human Influenza
Epilepsy
Fever

Keywords

  • Angina pectoris.
  • Antiepileptic drugs.
  • Folic acid
  • High fever related maternal diseases.
  • Hungarian Case-Control Surveillance of Congenital Abnormalities.
  • Hungarian periconception service.
  • Panic disorder.
  • Prevention of oral cleft.

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Czeizel, E., Vereczkey, A., & Bánhidy, F. (2013). Cleft lip and palate: Etiology and prevention. In Cleft Lip and Palate: Etiology, Surgery and Repair and Sociopsychological Consequences (pp. 1-53). Nova Science Publishers, Inc..

Cleft lip and palate : Etiology and prevention. / Czeizel, E.; Vereczkey, Attila; Bánhidy, F.

Cleft Lip and Palate: Etiology, Surgery and Repair and Sociopsychological Consequences. Nova Science Publishers, Inc., 2013. p. 1-53.

Research output: Chapter in Book/Report/Conference proceedingChapter

Czeizel, E, Vereczkey, A & Bánhidy, F 2013, Cleft lip and palate: Etiology and prevention. in Cleft Lip and Palate: Etiology, Surgery and Repair and Sociopsychological Consequences. Nova Science Publishers, Inc., pp. 1-53.
Czeizel E, Vereczkey A, Bánhidy F. Cleft lip and palate: Etiology and prevention. In Cleft Lip and Palate: Etiology, Surgery and Repair and Sociopsychological Consequences. Nova Science Publishers, Inc. 2013. p. 1-53
Czeizel, E. ; Vereczkey, Attila ; Bánhidy, F. / Cleft lip and palate : Etiology and prevention. Cleft Lip and Palate: Etiology, Surgery and Repair and Sociopsychological Consequences. Nova Science Publishers, Inc., 2013. pp. 1-53
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