Claudins and tricellulin in fibrolamellar hepatocellular carcinoma.

Attila Patonai, Boglárka Erdélyi-Belle, Anna Korompay, Aron Somorácz, Beate K. Straub, Peter Schirmacher, I. Kovalszky, G. Lotz, András Kiss, Z. Schaff

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25 Citations (Scopus)

Abstract

Fibrolamellar hepatocellular carcinoma is a subtype of hepatocellular carcinoma occurring in non-cirrhotic liver at a younger age. The tumor expresses both hepatocellular and cholangiocellular markers. Previously, our group described overexpression of tight junction protein claudin 4 in cholangiocellular carcinoma in contrast to hepatocellular carcinoma. In the present study, tight junction protein expressions were studied to possibly clarify bipotential lineage of fibrolamellar hepatocellular carcinoma. Eleven fibrolamellar hepatocellular carcinomas were compared with seven "conventional" hepatocellular carcinomas, seven cholangiocellular carcinomas, and five normal liver samples. By immunohistochemistry, all fibrolamellar hepatocellular carcinomas were positive for HepPar1 and cytokeratins 7, 8, and 18, but negative for cytokeratin 19. Glypican-3 gave weak staining in two cases. Expression of claudin 1 was lower, while that of claudin 2 was higher in fibrolamellar hepatocellular carcinomas than in other tumors. Claudins 3, 4, and 7 were not detectable in fibrolamellar hepatocellular carcinomas as in the majority of "conventional" hepatocellular carcinomas, contrary to high expression observed in cholangiocellular carcinomas. Focal or diffuse claudin 5 expression was detected in nine of 11 fibrolamellar hepatocellular carcinomas contrary to other tumors. Tricellulin was significantly downregulated in all tumors compared with normal liver. Our findings showed claudins to exhibit specific expression patterns in fibrolamellar hepatocellular carcinomas not observed in other primary liver tumors, with unique claudin 5 expression and pattern features similar to common hepatocellular carcinoma, but different from cholangiocellular carcinoma. This is the first report describing the loss of tricellulin expression in human hepatic tumors.

Original languageEnglish
Pages (from-to)679-688
Number of pages10
JournalVirchows Archiv : an international journal of pathology
Volume458
Issue number6
DOIs
Publication statusPublished - Jan 1 2011

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MARVEL Domain Containing 2 Protein
Claudins
Cholangiocarcinoma
Hepatocellular Carcinoma
Claudin-5
Liver
Tight Junction Proteins
Neoplasms
Claudin-2
Claudin-4
Glypicans
Claudin-1
Keratin-8
Keratin-7
Keratin-18
Keratin-19
Fibrolamellar hepatocellular carcinoma
Down-Regulation
Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Patonai, A., Erdélyi-Belle, B., Korompay, A., Somorácz, A., Straub, B. K., Schirmacher, P., ... Schaff, Z. (2011). Claudins and tricellulin in fibrolamellar hepatocellular carcinoma. Virchows Archiv : an international journal of pathology, 458(6), 679-688. https://doi.org/10.1007/s00428-011-1077-y

Claudins and tricellulin in fibrolamellar hepatocellular carcinoma. / Patonai, Attila; Erdélyi-Belle, Boglárka; Korompay, Anna; Somorácz, Aron; Straub, Beate K.; Schirmacher, Peter; Kovalszky, I.; Lotz, G.; Kiss, András; Schaff, Z.

In: Virchows Archiv : an international journal of pathology, Vol. 458, No. 6, 01.01.2011, p. 679-688.

Research output: Contribution to journalArticle

Patonai, A, Erdélyi-Belle, B, Korompay, A, Somorácz, A, Straub, BK, Schirmacher, P, Kovalszky, I, Lotz, G, Kiss, A & Schaff, Z 2011, 'Claudins and tricellulin in fibrolamellar hepatocellular carcinoma.', Virchows Archiv : an international journal of pathology, vol. 458, no. 6, pp. 679-688. https://doi.org/10.1007/s00428-011-1077-y
Patonai A, Erdélyi-Belle B, Korompay A, Somorácz A, Straub BK, Schirmacher P et al. Claudins and tricellulin in fibrolamellar hepatocellular carcinoma. Virchows Archiv : an international journal of pathology. 2011 Jan 1;458(6):679-688. https://doi.org/10.1007/s00428-011-1077-y
Patonai, Attila ; Erdélyi-Belle, Boglárka ; Korompay, Anna ; Somorácz, Aron ; Straub, Beate K. ; Schirmacher, Peter ; Kovalszky, I. ; Lotz, G. ; Kiss, András ; Schaff, Z. / Claudins and tricellulin in fibrolamellar hepatocellular carcinoma. In: Virchows Archiv : an international journal of pathology. 2011 ; Vol. 458, No. 6. pp. 679-688.
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