Classes and subclasses of rat immunoglobulins: Interaction with the complement system and with staphylococcal protein A

G. A. Medgyesi, G. Füst, J. Gergely, H. Bazin

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Abstract

Classes and subclasses of rat immunoglobulins represented by monoclonal proteins and normal serum immunoglobulin fractions were tested for their ability to interact with the complement system and to bind staphylococcal protein A. IgM, IgG1 and IgG2a type proteins were found to bind C1 and to consume total complement. An IgA type protein was found to be anticomplementary without C1 binding, reflecting activation through the alternative pathway. IgG2c type proteins have neither C1 binding nor anticomplementary activity. SpA was found to combine with IgG1 and IgG2c but not with IgG2a and IgG2b. Two of three monoclonal IgM proteins and an IgA type protein were also found to interact with SpA.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalMolecular Immunology
Volume15
Issue number2
DOIs
Publication statusPublished - 1978

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Staphylococcal Protein A
Immunoglobulins
Proteins
Immunoglobulin A
Immunoglobulin M
Immunoglobulin G
Blood Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Classes and subclasses of rat immunoglobulins : Interaction with the complement system and with staphylococcal protein A. / Medgyesi, G. A.; Füst, G.; Gergely, J.; Bazin, H.

In: Molecular Immunology, Vol. 15, No. 2, 1978, p. 125-129.

Research output: Contribution to journalArticle

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