Clarification of anomalous chiroptical behaviour and determination of the absolute configuration of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine

Elemér Fogassy, Mária Ács, Gábor Tóth, Kálmán Simon, Tibor Láng, L. Ladányi, L. Párkányi

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An optically active hydrogen bromide salt of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine has been prepared and the R5 configuration studied by single-crystal X-ray analysis. The crystals are triclinic with space group P1, with two molecules in a unit cell of dimensions a = 10.798(1), b = 12.669(1) and c = 8.681(1) Å, and α = 97.15(1), β = 99.36(1) and γ = 68.74(1)°. The anomalous chiroptical behaviour is explained on the basis of the chiral interactions between the optically active conformers.

Original languageEnglish
Pages (from-to)143-154
Number of pages12
JournalJournal of Molecular Structure
Issue number1-2
Publication statusPublished - Sep 1986


ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

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